Targeted delivery of therapeutic molecules into cancer cells is considered as a promising
strategy to tackle cancer. Antibody–drug conjugates (ADCs), in which a monoclonal …

Over the past couple of decades, antibody–drug conjugates (ADCs) have revolutionized the
field of cancer chemotherapy. Unlike conventional treatments that damage healthy tissues …

A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six
hypervariable regions from the heavy-and light-chain variable domains of a rat antibody …

The anti-Tac monoclonal antibody is known to bind to the p55 chain of the human interleukin
2 receptor and to inhibit proliferation of T cells by blocking interleukin 2 binding. However …

Cell lines have been established that secrete a matched set of human chimeric IgM, IgG1,
IgG2, IgG3, IgG4, IgE, and IgA2 antibodies that are directed against the hapten 4-hydroxy-3 …

A chimeric mouse-human Fab protein that binds specifically to the human carcinoma cell
line C3347 has been expressed and secreted from Escherichia coli. This molecule, which …

Abstract Treatment of cancer is a double-edged sword: it should be as aggressive as
possible to completely destroy the tumour, but it is precisely this aggressiveness which often …

JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z, 12Z-octadecadienoyl)-sn-
glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC (= O) OC [C …

The HER2 protooncogene encodes a receptor tyrosine kinase, p185 HER2. The
overexpression of p185 HER2 has been associated with a worsened prognosis in certain …

A mouse/human chimeric monoclonal antibody (mAb) composed of the variable regions of
murine 17-1A mAb and the constant regions of human IgG-1K immunoglobulin was …