Advances in molecular agents targeting toll-like receptor 4 signaling pathways for potential treatment of sepsis

Y Zheng, Y Gao, W Zhu, X Bai, J Qi - European Journal of Medicinal …, 2024 - Elsevier
Sepsis is a systemic inflammatory response syndrome caused by an infection. Toll-like
receptor 4 (TLR4) is activated by endogenous molecules released by injured or necrotic …

[HTML][HTML] Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications

J Wang, X Tao, Z Liu, Y Yan, P Cheng, B Liu… - Pharmacological …, 2025 - Elsevier
Sepsis is a life-threatening syndrome characterized by organ dysfunction caused by a
dysregulated host response to infection. Sepsis-associated acute liver injury (SA-ALI) is a …

Single‐cell RNA sequencing reveals reduced intercellular adhesion molecule crosstalk between activated hepatic stellate cells and neutrophils alleviating liver …

L Chen, Y Huang, N Zhang, J Qu, Y Fang, J Fu… - MedComm, 2024 - Wiley Online Library
Liver fibrosis can cause hepatitis B virus (HBV)‐associated hepatocellular carcinoma.
Menstrual blood‐derived mesenchymal stem cells (MenSCs) can ameliorate liver fibrosis …

LncRNA 220: A Novel Long Non-Coding RNA Regulates Autophagy and Apoptosis in Kupffer Cells via the miR-5101/PI3K/AKT/mTOR Axis in LPS-Induced …

Y Yang, T Tian, S Li, N Li, H Luo, Y Jiang - International Journal of …, 2023 - mdpi.com
Sepsis is a severe medical condition distinguished by immune systematic dysfunction and
multiple organic injury, or even failure, resulting from an acute systemic inflammatory …

Pretreatment of artesunate promoted hepatocyte proliferation by activating the PI3K/Akt/mTOR signaling pathway in mice

C Lu, X Li, C Fang, C Li, Y Xu, Y Guo - Acta Cirúrgica Brasileira, 2024 - SciELO Brasil
Purpose: Artesunate (ART) has been implicated in regulating the many processes of liver
injury, but its roles in liver regeneration still need to be illustrated. Methods: In the present …

Regeneration of Non-Alcoholic Fatty Liver Cells Using Chimeric FGF21/HGFR: A Novel Therapeutic Approach

SJ Kim, SJ Kim, J Hyun, HW Kim, JH Jang - International Journal of …, 2024 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant liver ailment
attributed to factors like obesity and diabetes. While ongoing research explores treatments …

Usp9x contributes to the development of sepsis-induced acute kidney injury by promoting inflammation and apoptosis in renal tubular epithelial cells via activation of …

S Gong, H Xiong, Y Lei, S Huang, Y Ouyang, C Cao… - Renal …, 2024 - Taylor & Francis
As a pattern recognition receptor, Toll-like receptor 4 (TLR4) is crucial for the development
and progression of acute kidney injury (AKI). This study aims to explore whether the …

Effect of endothelial responses on sepsis-associated organ dysfunction

W Miao, Y Yan, X Xinyu, B Jiawei, M Chengtai… - Chinese Medical …, 2024 - mednexus.org
Sepsis-related organ dysfunction is associated with increased morbidity and mortality.
Previous studies have found that the endothelium plays crucial roles in maintaining the …

[PDF][PDF] Research progress of oxidative stress in sepsis-associat-ed liver injury

H Su, T Xu, R Sun, Y Xiang, Y Gao, K Zai, S Fang - zentimepublishing.com
Sepsis is a systemic inflammatory response that caused by infection or trauma, often
resulting in multiple organ dysfunction. Its mortality rate is relatively high, ranging between …

The Endogenous Mechanism and Implementation Path of

Y Ying - Adult and Higher Education, 2024 - clausiuspress.com
In order to achieve the goal of" sports+ moral education" in universities, it has become a
consensus in the education industry to provide comprehensive and comprehensive moral …