Cause and consequence of heterogeneity in human mesenchymal stem cells: challenges in clinical application

Z Lyu, M Xin, DR Oyston, T Xue, H Kang… - … -Research and Practice, 2024 - Elsevier
Human mesenchymal stem cells (hMSCs) are mesoderm-derived adult stem cells with self-
proliferation capacity, pluripotent differentiation potency, and excellent histocompatibility …

[HTML][HTML] Immunotherapy in soft tissue and bone sarcoma: unraveling the barriers to effectiveness

M Panagi, P Pilavaki, A Constantinidou… - Theranostics, 2022 - ncbi.nlm.nih.gov
Sarcomas are uncommon malignancies of mesenchymal origin that can arise throughout the
human lifespan, at any part of the body. Surgery remains the optimal treatment modality …

From genomics to metabolomics: emerging metastatic biomarkers in osteosarcoma

DC Dean, S Shen, FJ Hornicek, Z Duan - Cancer and Metastasis Reviews, 2018 - Springer
Although the investigation into biomarkers specific for pulmonary metastasis within
osteosarcoma (OS) has recently expanded, their usage within the clinic remains sparse. The …

Exosomes secreted by adipose-derived mesenchymal stem cells foster metastasis and osteosarcoma proliferation by increasing COLGALT2 expression

Y Wang, Y Chu, K Li, G Zhang, Z Guo, X Wu… - Frontiers in cell and …, 2020 - frontiersin.org
Objectives Homosapien collagen beta (1-O) galactosyl transferase 2 (COLGALT2) is an
important enzyme during collagen glycosylation, yet its biological functions in cancer are …

Mesenchymal stem cells in renal fibrosis: the flame of cytotherapy

Q Zhuang, R Ma, Y Yin, T Lan, M Yu… - Stem cells …, 2019 - Wiley Online Library
Renal fibrosis, as the fundamental pathological process of chronic kidney disease (CKD), is
a pathologic extension of the normal wound healing process characterized by endothelium …

A spheroid model of early and late‐stage osteosarcoma mimicking the divergent relationship between tumor elimination and bone regeneration

FE Freeman, R Burdis, OR Mahon… - Advanced Healthcare …, 2022 - Wiley Online Library
Osteosarcoma is the most diagnosed bone tumor in children. The use of tissue engineering
strategies after malignant tumor resection remains a subject of scientific controversy. As a …

[HTML][HTML] Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice

A Stamatopoulos, T Stamatopoulos, Z Gamie… - Journal of bone …, 2019 - Elsevier
Over the past few decades, there has been growing interest in understanding the molecular
mechanisms of cancer pathogenesis and progression, as it is still associated with high …

An overview of mesenchymal stem cells and their potential therapeutic benefits in cancer therapy

SK Lim, BY Khoo - Oncology Letters, 2021 - spandidos-publications.com
There has been increased interest in using stem cells for regenerative medicine and cancer
therapy in the past decade. Mesenchymal stem cells (MSCs) are among the most studied …

Targeted therapies and checkpoint inhibitors in sarcoma

M Vasella, E Gousopoulos, M Guidi… - … Journal of Medicine, 2022 - academic.oup.com
Sarcomas are defined as a group of mesenchymal malignancies with over 100
heterogeneous subtypes. As a rare and difficult to diagnose entity, micrometastasis is …

DNA-binding cell-penetrating peptide-based TRAIL over-expression in Adipose tissue-derived mesenchymal stem cells inhibits glioma U251MG growth

J Shin, SK Baik, Y Yoon, S Hwang, JH Sohn… - Anticancer …, 2021 - ar.iiarjournals.org
Background/Aim: Genetic manipulation of stem cells using non-viral vectors is still limited
due to low transfection efficiency. We investigated whether the DNA-binding cell-permeation …