Inherited mitochondrial DNA (mtDNA) diseases were discovered 30 years ago, and their
characterization has provided a new perspective on the etiology of the common metabolic …

Background The integration of biological, psychological, and social factors in medicine has
benefited from increasingly precise stress response biomarkers. Mitochondria, a subcellular …

Human mitochondrial DNA (mtDNA) shows extensive within-population sequence
variability. Many studies suggest that mtDNA variants may be associated with ageing or …

Invasive species are increasingly affecting agriculture, food, fisheries, and forestry resources
throughout the world. As a result of global trade, invasive species are often introduced into …

Accumulating data highlight the contribution of brain mitochondria and bioenergetics to
psychiatric disorders and stress-related pathologies. Although anxiety has not received …

Mitochondria and mitochondrial DNA (mtDNA) variation are now recognized as important
factors in the development of osteoarthritis (OA). Mitochondria are the energy powerhouses …

Many epidemiologic studies have associated human mitochondrial haplogroups to rare
mitochondrial diseases like Leber's hereditary optic neuropathy or to more common age …

Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease
worldwide. NAFLD is tightly linked to the metabolic syndrome, insulin resistance, and …

Cytoplasmic hybrid (cybrid) cell lines can incorporate human subject mitochondria and
perpetuate its mitochondrial DNA (mtDNA)-encoded components. Since the nuclear …

Hematopoietic stem cells (HSCs) undergo rapid expansion in response to stress stimuli.
Here we investigate the bioenergetic processes which facilitate the HSC expansion in …