Crosstalk between bone and nerves within bone

QQ Wan, WP Qin, YX Ma, MJ Shen, J Li… - Advanced …, 2021 - Wiley Online Library
For the past two decades, the function of intrabony nerves on bone has been a subject of
intense research, while the function of bone on intrabony nerves is still hidden in the corner …

Semaphorins in adult nervous system plasticity and disease

D Carulli, F De Winter, J Verhaagen - Frontiers in synaptic …, 2021 - frontiersin.org
Semaphorins, originally discovered as guidance cues for developing axons, are involved in
many processes that shape the nervous system during development, from neuronal …

Remote neuronal activity drives glioma progression through SEMA4F

E Huang-Hobbs, YT Cheng, Y Ko, E Luna-Figueroa… - Nature, 2023 - nature.com
The tumour microenvironment plays an essential role in malignancy, and neurons have
emerged as a key component of the tumour microenvironment that promotes tumourigenesis …

Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF

A Antoniou, L Auderset, L Kaurani, E Sebastian… - Cell reports, 2023 - cell.com
Extracellular vesicles (EVs) have emerged as mediators of cellular communication, in part
via the delivery of associated microRNAs (miRNAs), small non-coding RNAs that regulate …

Pleiotropic meta-analysis of cognition, education, and schizophrenia differentiates roles of early neurodevelopmental and adult synaptic pathways

M Lam, WD Hill, JW Trampush, J Yu, E Knowles… - The American Journal of …, 2019 - cell.com
Susceptibility to schizophrenia is inversely correlated with general cognitive ability at both
the phenotypic and the genetic level. Paradoxically, a modest but consistent positive genetic …

The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

JY Lee, DJ Harney, JD Teo, JB Kwok… - Molecular …, 2023 - Springer
Background The risk for dementia increases exponentially from the seventh decade of life.
Identifying and understanding the biochemical changes that sensitize the ageing brain to …

Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system

N Vilallongue, J Schaeffer, AM Hesse… - Nature …, 2022 - nature.com
In the injured adult central nervous system (CNS), activation of pro-growth molecular
pathways in neurons leads to long-distance regeneration. However, most regenerative …

Genotype–phenotype correlation in Phelan‐McDermid syndrome: a comprehensive review of chromosome 22q13 deleted genes

A Ricciardello, P Tomaiuolo… - American Journal of …, 2021 - Wiley Online Library
Abstract Phelan‐McDermid syndrome (PMS, OMIM# 606232), also known as chromosome
22q13 deletion syndrome, is a rare genetic disorder characterized by intellectual disability …

Roles and mechanisms of axon-guidance molecules in Alzheimer's disease

L Zhang, Z Qi, J Li, M Li, X Du, S Wang, G Zhou… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by
progressive memory decline and cognitive dysfunctions. Although the causes of AD have …

Single-cell transcriptome identifies molecular subtype of autism spectrum disorder impacted by de novo loss-of-function variants regulating glial cells

N Nassir, A Bankapur, B Samara, A Ali, A Ahmed… - Human Genomics, 2021 - Springer
Background In recent years, several hundred autism spectrum disorder (ASD) implicated
genes have been discovered impacting a wide range of molecular pathways. However, the …