The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration
Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …
functionally conserved regulator of organ size and growth with crucial roles in cell …
The Hippo signaling pathway in stem cell biology and cancer
The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and
Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue …
Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue …
Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size
T Heallen, M Zhang, J Wang, M Bonilla-Claudio… - Science, 2011 - science.org
Genetic regulation of mammalian heart size is poorly understood. Hippo signaling
represents an organ-size control pathway in Drosophila, where it also inhibits cell …
represents an organ-size control pathway in Drosophila, where it also inhibits cell …
Hippo signaling impedes adult heart regeneration
Heart failure due to cardiomyocyte loss after ischemic heart disease is the leading cause of
death in the United States in large part because heart muscle regenerates poorly. The …
death in the United States in large part because heart muscle regenerates poorly. The …
Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2
Here we show that Mst1, a proapoptotic kinase, impairs protein quality control mechanisms
in the heart through inhibition of autophagy. Stress-induced activation of Mst1 in …
in the heart through inhibition of autophagy. Stress-induced activation of Mst1 in …
YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy
A von Gise, Z Lin, K Schlegelmilch… - Proceedings of the …, 2012 - National Acad Sciences
Heart growth is tightly controlled so that the heart reaches a predetermined size. Fetal heart
growth occurs through cardiomyocyte proliferation, whereas postnatal heart growth involves …
growth occurs through cardiomyocyte proliferation, whereas postnatal heart growth involves …
Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model
Rationale: Yes-associated protein (YAP), the terminal effector of the Hippo signaling
pathway, is crucial for regulating embryonic cardiomyocyte proliferation. Objective: We …
pathway, is crucial for regulating embryonic cardiomyocyte proliferation. Objective: We …
The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway
N Furth, Y Aylon - Cell Death & Differentiation, 2017 - nature.com
Proper cellular functionality and homeostasis are maintained by the convergent integration
of various signaling cascades, which enable cells to respond to internal and external …
of various signaling cascades, which enable cells to respond to internal and external …
A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response
The Hippo pathway is an evolutionarily conserved regulator of organ size and tumorigenesis
that negatively regulates cell growth and survival. Here we report that Yes-associated …
that negatively regulates cell growth and survival. Here we report that Yes-associated …
The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy
Rationale: Mutations in the intercalated disc proteins, such as plakophilin 2 (PKP2), cause
arrhythmogenic cardiomyopathy (AC). AC is characterized by the replacement of cardiac …
arrhythmogenic cardiomyopathy (AC). AC is characterized by the replacement of cardiac …