Surgery and drug therapy are the two principal options for cancer treatment. However, their
clinical benefits are hindered by the difficulty of accurate location of the tumors and timely …

Real-time intraoperative guidance is essential during oncological surgery for complete and
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …

Inadequate surgical margins occur frequently in oral squamous cell carcinoma surgery.
Fluorescence molecular imaging (FMI) has been explored for intraoperative margin …

Fluorescence-guided surgery is an intraoperative optical imaging method that provides
surgeons with real-time guidance for the delineation of tumours. Currently, in phase 1 and 2 …

Intraoperative fluorescent imaging can provide real-time identification of tumours, lymph
nodes, nerves and other healthy and malignant tissues during oncological surgery …

Clear delineation of tumor margins is essential for accurate resection and decreased
recurrence rate in the clinic. Fluorescence imaging is emerging as a promising alternative to …

Cancer cell metabolism leads to a uniquely acidic microenvironment in solid tumors, but
exploiting the labile extracellular pH differences between cancer and normal tissues for …

Real-time and accurate guidance for tumor resection has long been anticipated by
surgeons. In the past decade, the flourishing material science has made impressive …

The pathological assessment of surgical specimens during surgery can reduce the
incidence of positive resection margins, which otherwise can result in additional surgeries or …

Poor tissue penetration remains a major challenge for antibody-based therapeutics of solid
tumors, but proper dosing can improve the tissue penetration and thus therapeutic efficacy of …