[HTML][HTML] Psoriasis pathogenesis and treatment

A Rendon, K Schäkel - International journal of molecular sciences, 2019 - mdpi.com
Research on psoriasis pathogenesis has largely increased knowledge on skin biology in
general. In the past 15 years, breakthroughs in the understanding of the pathogenesis of …

Psoriatic arthritis from a mechanistic perspective

G Schett, P Rahman, C Ritchlin, IB McInnes… - Nature Reviews …, 2022 - nature.com
Psoriatic arthritis (PsA) is part of a group of closely related clinical phenotypes ('psoriatic
disease') that is defined by shared molecular pathogenesis resulting in excessive …

Management of psoriasis as a systemic disease: what is the evidence?

NJ Korman - British Journal of Dermatology, 2020 - academic.oup.com
Background Psoriasis is a chronic, systemic immune‐mediated disease characterized by
development of erythematous, indurated, scaly, pruritic and often painful skin plaques …

Psoriasis and comorbid diseases: epidemiology

J Takeshita, S Grewal, SM Langan, NN Mehta… - Journal of the American …, 2017 - Elsevier
Psoriasis is a common chronic inflammatory disease of the skin that is increasingly being
recognized as a systemic inflammatory disorder. Psoriatic arthritis is a well-known …

[HTML][HTML] Systemic inflammation and cardiovascular comorbidity in psoriasis patients: causes and consequences

WH Boehncke - Frontiers in immunology, 2018 - frontiersin.org
Psoriasis is a common inflammatory skin disease characterized by the appearance of red
scaly plaques that can affect any part of the body. High prevalence, chronicity, disfiguration …

Psoriasis severity and the prevalence of major medical comorbidity: a population-based study

H Yeung, J Takeshita, NN Mehta, SE Kimmel… - JAMA …, 2013 - jamanetwork.com
Importance Despite the growing literature on comorbidity risks in psoriasis, there remains a
critical knowledge gap on the degree to which objectively measured psoriasis severity may …

Psoriasis and metabolic syndrome: implications for the management and treatment of psoriasis

JJ Wu, A Kavanaugh, MG Lebwohl… - Journal of the …, 2022 - Wiley Online Library
Psoriasis is a chronic systemic inflammatory disorder associated with several comorbidities
in addition to the characteristic skin lesions. Metabolic syndrome (MetS) is the most frequent …

[HTML][HTML] Impact of secukinumab on endothelial dysfunction and other cardiovascular disease parameters in psoriasis patients over 52 weeks

E von Stebut, K Reich, D Thaçi, W Koenig… - Journal of Investigative …, 2019 - Elsevier
Psoriasis increases the risk of cardiovascular (CV) disease. Secukinumab, a fully human
monoclonal antibody against IL-17A, shows significant efficacy in psoriasis, but effects on …

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses

MA Lowes, CB Russell, DA Martin, JE Towne… - Trends in …, 2013 - cell.com
Psoriasis is a complex inflammatory process resulting from activation of the well-defined
interleukin (IL)-23/T17 cytokine axis. We review the role of key cytokines IL-17 and IL-23 in …

[HTML][HTML] Psoriasis and cardiovascular comorbidities: focusing on severe vascular events, cardiovascular risk factors and implications for treatment

SCS Hu, CCE Lan - International journal of molecular sciences, 2017 - mdpi.com
Psoriasis is a common and chronic inflammatory disease of the skin. It may impair the
physical and psychosocial function of patients and lead to decreased quality of life …