Motile cilia are highly complex hair-like organelles of epithelial cells lining the surface of
various organ systems. Genetic mutations (usually with autosomal recessive inheritance) …

Cilia are ubiquitous microtubule-based eukaryotic organelles that project from the cell to
generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal …

This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …

Comparative studies on brain asymmetry date back to the 19th century but then largely
disappeared due to the assumption that lateralization is uniquely human. Since the …

Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …

Congenital heart disease is the most common birth defect, and because of major advances
in medical and surgical management, there are now more adults living with congenital heart …

The breaking of bilateral symmetry in most vertebrates is critically dependent upon the
motile cilia of the embryonic left-right organizer (LRO), which generate a directional fluid …

Dynein-decorated doublet microtubules (DMTs) are critical components of the oscillatory
molecular machine of cilia, the axoneme, and have luminal surfaces patterned periodically …

Fluid dynamics plays a crucial role in many cellular processes, including the locomotion of
cells such as bacteria and spermatozoa. These organisms possess flagella, slender …

Eukaryotic cilia and flagella are evolutionarily conserved organelles that protrude from the
cell surface. The unique location and properties of cilia allow them to function in vital …