The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Immunosenescence is a series of age-related changes that affect the immune system and,
with time, lead to increased vulnerability to infectious diseases. This Review addresses …

Aging affects all tissues and organs. Aging of the immune system results in the severe
disruption of its functions, leading to an increased susceptibility to infections, an increase in …

Chikungunya virus (CHIKV), a single-stranded RNA virus transmitted by Aedes mosquitoes,
poses a significant global health threat, with severe complications observed in vulnerable …

Aging leads to numerous changes that affect many components of the immune system,
called “immunosenescence”. Indeed, elderly individuals exhibit dysregulated immune …

Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the
thymus microenvironment provide essential signals to self-reactive thymocytes that induce …

Chikungunya virus (CHIKV) is currently one of the most relevant arboviruses to public
health. It is a member of the Togaviridae family and alphavirus genus and causes an …

Adults over 65 years of age are more vulnerable to infectious disease and show poor
responses to vaccination relative to those under 50. A complex set of age-related changes in …

Aging is characterized by progressive loss of organ and tissue function, and the immune
system is no exception to that inevitable principle. Of all the age-related changes in the …

The immune system is a major regulatory system of the body, that is composed of immune
cells, immune organs, and related signaling factors. As an organism ages, observable age …