The kainic acid model of temporal lobe epilepsy has greatly contributed to the
understanding of the molecular, cellular and pharmacological mechanisms underlying …

Experimental models of epilepsy are useful to identify potential mechanisms of
epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) …

In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to
develop new pharmacological treatments, in vivo animal models that present features …

Acquired epilepsy (ie, after an insult to the brain) is often considered to be a progressive
disorder, and the nature of this hypothetical progression remains controversial. Antiepileptic …

Post-traumatic epilepsy continues to be a major concern for those experiencing traumatic
brain injury. Post-traumatic epilepsy accounts for 10–20% of epilepsy cases in the general …

Precision medicine can be defined as the prevention, investigation and treatment of
diseases taking individual variability into account. There are multiple ways in which the field …

Interictal spikes are widely accepted diagnostically as a sign of epilepsy, but reasons for the
presence of interictal activity in the epileptic brain are unknown. Interictal spikes are easily …

Pilocarpine administration to rats results in status epilepticus (SE) and after a latency period
to the occurrence of spontaneous seizures. The model is commonly used to investigate …

Animal models of epilepsy and seizures, mostly involving mice and rats, are used to
understand the pathophysiology of the different forms of epilepsy and their comorbidities, to …

The development of acquired epilepsy after a perinatal hypoxic–ischemic (HI) insult was
investigated in rats. After unilateral carotid ligation with hypoxia on postnatal day 7, cortical …