[HTML][HTML] Replicative and chronological aging in Saccharomyces cerevisiae
Saccharomyces cerevisiae has directly or indirectly contributed to the identification of
arguably more mammalian genes that affect aging than any other model organism. Aging in …
arguably more mammalian genes that affect aging than any other model organism. Aging in …
Is antagonistic pleiotropy ubiquitous in aging biology?
SN Austad, JM Hoffman - Evolution, medicine, and public health, 2018 - academic.oup.com
Abstract Lay Summary: An evolutionary mechanism of aging was hypothesized 60 years
ago to be the genetic trade-off between early life fitness and late life mortality. Genetic …
ago to be the genetic trade-off between early life fitness and late life mortality. Genetic …
A comprehensive analysis of replicative lifespan in 4,698 single-gene deletion strains uncovers conserved mechanisms of aging
MA McCormick, JR Delaney, M Tsuchiya… - Cell metabolism, 2015 - cell.com
Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces
cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We …
cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We …
Budding yeast as a model organism to study the effects of age
A Denoth Lippuner, T Julou… - FEMS microbiology …, 2014 - academic.oup.com
Although a budding yeast culture can be propagated eternally, individual yeast cells age
and eventually die. The detailed knowledge of this unicellular eukaryotic species as well as …
and eventually die. The detailed knowledge of this unicellular eukaryotic species as well as …
Mitochondrial quality control during inheritance is associated with lifespan and mother–daughter age asymmetry in budding yeast
JR McFaline‐Figueroa, J Vevea, TC Swayne… - Aging cell, 2011 - Wiley Online Library
Fluorescence loss in photobleaching experiments and analysis of mitochondrial function
using superoxide and redox potential biosensors revealed that mitochondria within …
using superoxide and redox potential biosensors revealed that mitochondria within …
[HTML][HTML] The yeast replicative aging model
It has been nearly three decades since the budding yeast Saccharomyces cerevisiae
became a significant model organism for aging research and it has emerged as both simple …
became a significant model organism for aging research and it has emerged as both simple …
Pleiotropy, epistasis and the genetic architecture of quantitative traits
TFC Mackay, RRH Anholt - Nature Reviews Genetics, 2024 - nature.com
Pleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis
(whereby non-linear interactions between genetic polymorphisms affect the same trait) are …
(whereby non-linear interactions between genetic polymorphisms affect the same trait) are …
Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast
Replicative aging in yeast is asymmetric–mother cells age but their daughter cells are
rejuvenated. Here we identify an asymmetry in pH between mother and daughter cells that …
rejuvenated. Here we identify an asymmetry in pH between mother and daughter cells that …
Aging of the retina: molecular and metabolic turbulences and potential interventions
Multifaceted and divergent manifestations across tissues and cell types have curtailed
advances in deciphering the cellular events that accompany advanced age and contribute to …
advances in deciphering the cellular events that accompany advanced age and contribute to …
Evidence for the role of selection for reproductively advantageous alleles in human aging
The antagonistic pleiotropy hypothesis posits that natural selection for pleiotropic mutations
that confer earlier or more reproduction but impair the post-reproductive life causes aging …
that confer earlier or more reproduction but impair the post-reproductive life causes aging …