Applications of focused ultrasound in the brain: from thermoablation to drug delivery
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …
clinic represents the culmination of decades of research. Lying at the convergence of …
[HTML][HTML] Ultrasound neuromodulation: a review of results, mechanisms and safety
Ultrasonic neuromodulation is a rapidly growing field, in which low-intensity ultrasound (US)
is delivered to nervous system tissue, resulting in transient modulation of neural activity. This …
is delivered to nervous system tissue, resulting in transient modulation of neural activity. This …
Ultrasound technologies for imaging and modulating neural activity
Visualizing and perturbing neural activity on a brain-wide scale in model animals and
humans is a major goal of neuroscience technology development. Established electrical and …
humans is a major goal of neuroscience technology development. Established electrical and …
Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound
Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …
Sonication of the anterior thalamus with MRI-Guided transcranial focused ultrasound (tFUS) alters pain thresholds in healthy adults: A double-blind, sham-controlled …
Background: Transcranial focused ultrasound (tFUS) is a noninvasive brain stimulation
method that may modulate deep brain structures. This study investigates whether sonication …
method that may modulate deep brain structures. This study investigates whether sonication …
Holograms to focus arbitrary ultrasonic fields through the skull
We report three-dimensional (3D)-printed acoustic holographic lenses for the formation of
ultrasonic fields of complex spatial distribution inside the skull. Using holographic lenses, we …
ultrasonic fields of complex spatial distribution inside the skull. Using holographic lenses, we …
A clinical system for non-invasive blood–brain barrier opening using a neuronavigation-guided single-element focused ultrasound transducer
Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is currently being
investigated in clinical trials. Here, we describe a portable clinical system with a therapeutic …
investigated in clinical trials. Here, we describe a portable clinical system with a therapeutic …
Design and micromanufacturing technologies of focused piezoelectric ultrasound transducers for biomedical applications
X Bai, D Wang, L Zhen, M Cui, J Liu… - … Journal of Extreme …, 2024 - iopscience.iop.org
Piezoelectric ultrasonic transducers have shown great potential in biomedical applications
due to their high acoustic-to-electric conversion efficiency and large power capacity. The …
due to their high acoustic-to-electric conversion efficiency and large power capacity. The …
Therapeutic agent delivery across the blood–brain barrier using focused ultrasound
D McMahon, MA O'Reilly… - Annual Review of …, 2021 - annualreviews.org
Specialized features of vasculature in the central nervous system greatly limit therapeutic
treatment options for many neuropathologies. Focused ultrasound, in combination with …
treatment options for many neuropathologies. Focused ultrasound, in combination with …
Exploiting the mechanical effects of ultrasound for noninvasive therapy
MA O'Reilly - Science, 2024 - science.org
Focused ultrasound is a platform technology capable of eliciting a wide range of biological
responses with high spatial precision deep within the body. Although focused ultrasound is …
responses with high spatial precision deep within the body. Although focused ultrasound is …