Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

Sumoylation is an essential post‐translational modification intimately involved in a diverse
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …

The SUMO protease SENP6 maintains genomic stability, but mechanistic understanding of
this process remains limited. We find that SENP6 deconjugates SUMO2/3 polymers on a …

Posttranslational modification by small ubiquitin-like modifiers (SUMOs) is critical in
regulating diverse cellular processes including gene expression, cell cycle progression …

Exposure of cells to heat or oxidative stress causes misfolding of proteins. To avoid toxic
protein aggregation, cells have evolved nuclear and cytosolic protein quality control (PQC) …

Small ubiquitin-like modifiers (SUMOs) regulate virtually all nuclear processes. The fate of
the target protein is determined by the architecture of the attached SUMO protein, which can …

Post-translational modification by Small Ubiquitin-like Modifier (SUMO) proteins regulates
numerous cellular processes. This modification involves the covalent and reversible …

Simple Summary Post-translational modification—the biochemical addition of functional
groups or proteins—occurs following protein biosynthesis and contributes to an increase in …

Simple Summary The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark
properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery …