The maintenance of genome stability depends on the DNA damage response (DDR), which
is a functional network comprising signal transduction, cell cycle regulation and DNA repair …

Inherited germline mutations in either BRCA1 or BRCA2 confer a significant lifetime risk of
developing breast or ovarian cancer. Defining how these two genes function at the cellular …

The ATR-Chk1 pathway is critical for DNA damage responses and cell-cycle progression.
Chk1 inhibition is more deleterious to cycling cells than ATR inhibition, raising questions …

DNA damage responses have been well characterized with regard to their cell-autonomous
checkpoint functions leading to cell cycle arrest, senescence and apoptosis. In contrast …

The ataxia-telangiectasia-mutated (ATM) and ATM-and Rad3-related (ATR) protein kinases
are crucial regulatory proteins in genotoxic stress response pathways that pause the cell …

The cellular DNA damage response (DDR) is activated by many types of DNA lesions. Upon
recognition of DNA damage by sensor proteins, an intricate signal transduction network is …

Germline apoptosis shares with somatic apoptosis a reliance on key components of the core
apoptotic machinery, including CED-3 and CED-4. However, germline apoptosis differs from …

Meiotic double-strand breaks (DSBs) are generated and repaired in a highly regulated
manner to ensure formation of crossovers (COs) while also enabling efficient non-CO repair …

Bisphenol A (BPA) is a highly prevalent constituent of plastics that has been associated with
diabetes, cardiovascular disease, and an increased risk of miscarriages in humans. In mice …

Exposure to endocrine disrupting compounds (EDCs), such as bisphenol A (BPA), may
cause adverse health effects in wildlife and humans, but controversy remains as to what …