Myocardial infarction (MI), an acute cardiovascular disease characterized by coronary artery
blockage, inadequate blood supply, and subsequent ischemic necrosis of the myocardium …

Hypoxia-inducible factors (HIFs) play a crucial role in cellular responses to low oxygen
levels during myocardial ischemia and reperfusion injury. HIF stabilizers, originally …

Diabetic cardiomyopathy (DCM) is a major contributor to mortality in diabetic patients,
characterized by a multifaceted pathogenesis and limited therapeutic options. While lactate …

We employed an early training exercise program, immediately after recovery from surgery,
and before severe cardiac hypertrophy, to study the underlying mechanism involved with the …

Administration of oxygen microbubbles (OMBs) has been shown to increase oxygen and
decrease carbon dioxide in systemic circulation, as well as reduce lung inflammation and …

The association between high-density lipoprotein (HDL) cholesterol and breast cancer (BC)
remains controversial due to the high complexity of the HDL particle and its functionality. The …

Gout is characterized by increased production of purines (through the pentose phosphate
pathway), which is coupled with reduced renal or intestinal excretion of urate. Concurrent …

Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have emerged as a novel
therapeutic class for treating anemia in patients with chronic kidney disease. Small molecule …

The effects of exercise training (ET) on the heart of aortic stenosis (AS) rats are controversial
and the mechanisms involved in alterations induced by ET have been poorly clarified. In this …

Desidustat is a small molecule inhibitor of hypoxia-inducible factor-prolyl hydroxylase (HIF-
PH) discovered and developed by Zydus Lifesciences for the treatment of anemia …