Lysosomes are acidic compartments filled with more than 60 different types of hydrolases.
They mediate the degradation of extracellular particles from endocytosis and of intracellular …

Abstract Changes in cytosolic free Ca 2+ concentration ([Ca 2+] c) play a crucial role in the
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is …

Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like
peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); …

Since the discovery of the Ca 2+ mobilizing effects of the pyridine nucleotide metabolite,
nicotinic acid adenine dinucleotide phosphate (NAADP), this molecule has been …

Insulin secretion from pancreatic β cells is stimulated by glucagon-like peptide-1 (GLP-1), a
blood glucose-lowering hormone that is released from enteroendocrine L cells of the distal …

Nicotinic acid adenine dinucleotide phosphate (NAADP) serves as the ideal trigger of spatio-
temporally complex intracellular Ca 2+ signals. However, the identity of the intracellular Ca …

Neurodegenerative diseases (ND) pose a serious health burden to society and healthcare
systems alike, with increasing incidence rates especially within aging populations …

Acidic organelles, such as endosomes and lysosomes, store Ca2+ that is released in
response to intracellular increases in the second messenger nicotinic acid adenine …

The concept advanced by Berridge and colleagues that intracellular Ca 2+-stores can be
mobilized in an agonist-dependent and messenger (IP 3)-mediated manner has put Ca 2+ …

The functional relationship between the formation of hundreds of fusion pores during the
acrosome reaction in spermatozoa and the mobilization of calcium from the acrosome has …