Astrocytes: role and functions in brain pathologies
Astrocytes are a population of cells with distinctive morphological and functional
characteristics that differ within specific areas of the brain. Postnatally, astrocyte progenitors …
characteristics that differ within specific areas of the brain. Postnatally, astrocyte progenitors …
Chronic glutamate toxicity in neurodegenerative diseases—what is the evidence?
J Lewerenz, P Maher - Frontiers in neuroscience, 2015 - frontiersin.org
Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain.
Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate …
Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate …
Amino acid transporters revisited: New views in health and disease
P Kandasamy, G Gyimesi, Y Kanai… - Trends in biochemical …, 2018 - cell.com
Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …
SLC transporters as therapeutic targets: emerging opportunities
Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …
facilitate the transport of a wide array of substrates across biological membranes—have …
Glutamate as a neurotransmitter in the healthy brain
Y Zhou, NC Danbolt - Journal of neural transmission, 2014 - Springer
Glutamate is the most abundant free amino acid in the brain and is at the crossroad between
multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate …
multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate …
De novo mutations in SLC1A2 and CACNA1A are important causes of epileptic encephalopathies
CT Myers, JM McMahon, AL Schneider… - The American Journal of …, 2016 - cell.com
Epileptic encephalopathies (EEs) are the most clinically important group of severe early-
onset epilepsies. Next-generation sequencing has highlighted the crucial contribution of de …
onset epilepsies. Next-generation sequencing has highlighted the crucial contribution of de …
Mechanisms of glutamate transport
RJ Vandenberg, RM Ryan - Physiological reviews, 2013 - journals.physiology.org
l-Glutamate is the predominant excitatory neurotransmitter in the mammalian central
nervous system and plays important roles in a wide variety of brain functions, but it is also a …
nervous system and plays important roles in a wide variety of brain functions, but it is also a …
Role of excitatory amino acid transporter‐2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics
Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory
amino acid transporter (EAAT)‐2 is one of the major glutamate transporters expressed …
amino acid transporter (EAAT)‐2 is one of the major glutamate transporters expressed …
The SLC1 high-affinity glutamate and neutral amino acid transporter family
Y Kanai, B Clémençon, A Simonin… - Molecular aspects of …, 2013 - Elsevier
Glutamate transporters play important roles in the termination of excitatory
neurotransmission and in providing cells throughout the body with glutamate for metabolic …
neurotransmission and in providing cells throughout the body with glutamate for metabolic …
Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease
K Takahashi, JB Foster, CLG Lin - Cellular and Molecular Life Sciences, 2015 - Springer
Glutamate is the predominant excitatory neurotransmitter in the central nervous system.
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …