Animal models of depression: what can they teach us about the human disease?

M Becker, A Pinhasov, A Ornoy - Diagnostics, 2021 - mdpi.com
Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

[HTML][HTML] Brain membrane lipids in major depression and anxiety disorders

CP Müller, M Reichel, C Mühle, C Rhein… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Major depression and anxiety disorders have high prevalence rates and are frequently
comorbid. The neurobiological bases for these disorders are not fully understood, and …

[HTML][HTML] Omega-3 fatty acids and the treatment of depression: a review of scientific evidence

SA Bhat, A Ara - Integrative medicine research, 2015 - Elsevier
Depression is a condition in which an individual feels lethargic, irritable, and guilty, has
difficulty and trouble, no enjoyment in life, mood swings, sometimes suicidal ideation and …

Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways

I Holzmann, LM da Silva, JAC da Silva… - Pharmacology …, 2015 - Elsevier
Olfactory bulbectomy (OB) is an animal model of depression that can mimic symptoms that
are characteristic of depressive patients, such as behavioral, neurochemical and …

[HTML][HTML] Neurolipidomic insights into anxiety disorders: Uncovering lipid dynamics for potential therapeutic advances

S Maehashi, K Arora, AL Fisher, DR Schweitzer… - Neuroscience & …, 2024 - Elsevier
Anxiety disorders constitute a spectrum of psychological conditions affecting millions of
individuals worldwide, imposing a significant health burden. Historically, the development of …

Antidepressant-like effects of salidroside on olfactory bulbectomy-induced pro-inflammatory cytokine production and hyperactivity of HPA axis in rats

SJ Yang, HY Yu, DY Kang, ZQ Ma, R Qu, Q Fu… - Pharmacology …, 2014 - Elsevier
Salidroside (SA) is the primary bioactive marker compound in the standardized extracts from
Rhodiola rosea. Although it has potential antidepressant activity in a rat behavioral despair …

A natural phenolic compound quercetin showed the usefulness by targeting inflammatory, oxidative stress markers and augment 5-HT levels in one of the animal …

K Khan, AK Najmi, M Akhtar - Drug Research, 2019 - thieme-connect.com
Aim In the present study quercetin was studied for its role in inflammation, oxidative stress
markers and 5-HT levels in unpredictable chronic mild stress (UCMS) animal model of …

Natural environments, ancestral diets, and microbial ecology: is there a modern “paleo-deficit disorder”? Part II

AC Logan, MA Katzman… - Journal of Physiological …, 2015 - Springer
Famed microbiologist René J. Dubos (1901–1982) was an early pioneer in the
developmental origins of health and disease (DOHaD) construct. In the 1960s, he conducted …

Diabetes exacerbates sepsis-induced neuroinflammation and brain mitochondrial dysfunction

S de Souza Stork, M Hübner, E Biehl, LG Danielski… - Inflammation, 2022 - Springer
Sepsis is a life-threatening organ dysfunction, which demands notable attention for its
treatment, especially in view of the involvement of immunodepressed patients, as the case of …

An increase in plasma brain derived neurotrophic factor levels is related to n-3 polyunsaturated fatty acid efficacy in first episode schizophrenia: secondary outcome …

T Pawełczyk, M Grancow-Grabka, E Trafalska… - …, 2019 - Springer
Rationale N− 3 polyunsaturated fatty acids (n− 3 PUFA) influence multiple biochemical
mechanisms postulated in the pathogenesis of schizophrenia that may influence BDNF …