This article reviews the major physiological and physicochemical principles of the effect of
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …

Obesity is a pathophysiological state defined by a body mass index> 30 kg/m 2 and
characterized by an adipose tissue accumulation leading to an important weight increased …

Therapeutic drug monitoring (TDM) may be required to achieve optimal clinical outcomes in
the setting of significant pharmacokinetic variability, a situation that applies to a number of …

Objectives The objectives of this study were to explore inter-study heterogeneity in the
pharmacokinetics (PK) of orally administered rifampicin, to derive summary estimates of …

This study aimed to conduct a quantitative meta-analysis for the values of, and variability in,
gastrointestinal (GI) pH in the different GI segments; characterize the effect of food on the …

This study aimed to conduct a quantitative meta-analysis for the values of, and variability in,
gastrointestinal (GI) transit times of non-disintegrating single-unit (“tablet”) and multiple-unit …

Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …

Abstract Itraconazole (ITC), a well-known fungistatic agent, has potent fungicidal activity
against Candida albicans. However, its mechanism of fungicidal activity has not been …

Despite enormous success in biomedical science and technology, as well as increased
research and development spending, pharmaceutical productivity has faced challenges …

Conventional itraconazole (c-ITZ) can be used for a variety of fungal infections although
variable absorption has been a significant limitation. Super-bioavailable itraconazole (SUBA …