The forkhead box O (FoxO) transcription factor family is a key player in an evolutionary
conserved pathway downstream of insulin and insulin-like growth factor receptors. The …

Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …

The kinase PINK1 and ubiquitin ligase Parkin can regulate the selective elimination of
damaged mitochondria through autophagy (mitophagy). Because of the demand on …

This chapter includes a historic overview of 14-3-3 proteins with an emphasis on the
differences between potentially cancer-relevant isoforms on the genomic, protein and …

Multiprotein signalling networks create focal points of enzyme activity that disseminate the
intracellular action of many hormones and neurotransmitters. Accordingly, the spatio …

The salt-inducible kinases, SIK1, SIK2 and SIK3, most closely resemble the AMP-activated
protein kinase (AMPK) and other AMPK-related kinases, and like these family members they …

Proteins are controlled by a vast and dynamic array of post-translational modifications, many
of which create binding sites for specific protein-interaction domains. We propose that these …

TNFR1 and TNFR2 have received prominent attention because of their dominance in the
pathogenesis of inflammation and autoimmunity. TNFR1 has been extensively studied and …

LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of
Parkinson's disease patients, but still little is understood about how it is regulated or …

The 14-3-3 proteins, a family of conserved regulatory molecules, participate in a wide range
of cellular processes through binding interactions with hundreds of structurally and …