Electron-Deficient Acetylenes as Three-Modal Adjuvants in SNH Reaction of Pyridinoids with Phosphorus Nucleophiles

BA Trofimov, PA Volkov, AA Telezhkin - Molecules, 2021 - mdpi.com
Publications covering a new easy metal-free functionalization of pyridinoids (pyridines,
quinolines, isoquinolines, acridine) under the action of the system of electron-deficient …

Design, synthesis and evaluation of novel 1, 2, 4-triazole derivatives as promising anticancer agents

L Emami, S Sadeghian, A Mojaddami, S Khabnadideh… - BMC chemistry, 2022 - Springer
Herein, we reported the synthesis of nineteen novel 1, 2, 4-triazole derivatives including 1, 3-
diphenyl-2-(1H-1, 2, 4-triazol-1-yl) propan-1-ones (7a-e), 1-(1, 3-diphenylpropan-2-yl)-1 H-1 …

Rollover cyclometalated bipyridine platinum complexes as potent anticancer agents: impact of the ancillary ligands on the mode of action

MV Babak, M Pfaffeneder-Kmen… - Inorganic …, 2018 - ACS Publications
Platinum-based anticancer coordination compounds are widely used in the treatment of
many tumor types, where they are very effective but also cause severe side effects …

Half-Sandwich Cyclometalated RhIII Complexes Bearing Thiolate Ligands: Biomolecular Interactions and In Vitro and In Vivo Evaluations

A Nahaei, Z Mandegani, S Chamyani… - Inorganic …, 2022 - ACS Publications
A class of cyclometalated RhIII complexes [Cp* Rh (ppy)(SR)] bearing thiolate ligands, Cp*=
pentamethylcyclopentadienyl, ppy= 2-phenylpyridinate, and R= pyridyl (Spy, 2), pyrimidyl …

Fluorinated cycloplatinated (II) complexes bearing bisphosphine ligands as potent anticancer agents

HR Shahsavari, J Hu, S Chamyani, Y Sakamaki… - …, 2020 - ACS Publications
A family of cationic cycloplatinated (II) complexes [Pt (dfppy)(P^ P)] Cl incorporating
bisphosphine ligands was prepared:(dfppy= 2-(2, 4-difluorophenyl) pyridine; P^ P= bis …

Palladium (II) complexes based on Schiff base ligands derived from ortho-vanillin; synthesis, characterization and cytotoxic studies

Z Faghih, A Neshat, A Wojtczak, Z Faghih… - Inorganica Chimica …, 2018 - Elsevier
Methoxy-2-[(E)-Aryliminomethyl]-phenol (Aryl= Phenyl; 2, 6-dimethyl; 2, 6-diisopropylphenyl;
2, 6-dichlorophenyl), comprising L 1–L 4 ligands, and palladium complexes [Pd (L n) 2, n= 1 …

Synthesis, characterization, and anticancer activity of benzothiazole aniline derivatives and their platinum (II) complexes as new chemotherapy agents

MK Islam, AR Baek, B Sung, BW Yang, G Choi… - Pharmaceuticals, 2021 - mdpi.com
We describe the synthesis, characterization, molecular modeling, and in vitro anticancer
activity of three benzothiazole aniline (BTA) ligands and their corresponding platinum (II) …

Cycloplatinated (II) derivatives of mercaptopurine capable of binding interactions with HSA/DNA

MD Aseman, S Aryamanesh, Z Shojaeifard… - Inorganic …, 2019 - ACS Publications
In this study, two new bis-cyclometalated Pt (II) complexes,[Pt (C^ N)(S^ N)][S^ N=
deprotonated 6-mercaptopurine (6-MP) and C^ N= deprotonated 2-phenylpyridine (ppy), 2a; …

Synthesis of a light-responsive platinum curcumin complex, chemical and biological investigations and delivery to tumor cells by means of polymeric nanoparticles

V Vergaro, MM Dell'Anna, HR Shahsavari… - Nanoscale …, 2023 - pubs.rsc.org
Platinum-based anticancer drugs are common in chemotherapy, but problems such as
systemic toxicity and acquired resistance of some tumors hamper their clinical applications …

Design, synthesis, molecular docking, biological evaluations and QSAR studies of novel dichloroacetate analogues as anticancer agent

M Fereidoonnezhad, SMH Tabaei, A Sakhteman… - Journal of Molecular …, 2020 - Elsevier
Dichloroacetate (DCA) as a mitochondria-targeting small molecule, through inhibition of
pyruvate dehydrogenase kinases (PDK 1-4), promotes mitochondria-regulated apoptosis …