Platinum-based anticancer coordination compounds are widely used in the treatment of many tumor types, where they are very effective but also cause severe side effects …
A family of cationic cycloplatinated (II) complexes [Pt (dfppy)(P^ P)] Cl incorporating bisphosphine ligands was prepared:(dfppy= 2-(2, 4-difluorophenyl) pyridine; P^ P= bis …
MK Islam, AR Baek, B Sung, BW Yang, G Choi… - Pharmaceuticals, 2021 - mdpi.com
We describe the synthesis, characterization, molecular modeling, and in vitro anticancer activity of three benzothiazole aniline (BTA) ligands and their corresponding platinum (II) …
In this study, two new bis-cyclometalated Pt (II) complexes,[Pt (C^ N)(S^ N)][S^ N= deprotonated 6-mercaptopurine (6-MP) and C^ N= deprotonated 2-phenylpyridine (ppy), 2a; …
Platinum-based anticancer drugs are common in chemotherapy, but problems such as systemic toxicity and acquired resistance of some tumors hamper their clinical applications …
Dichloroacetate (DCA) as a mitochondria-targeting small molecule, through inhibition of pyruvate dehydrogenase kinases (PDK 1-4), promotes mitochondria-regulated apoptosis …