Measuring biological age using omics data
J Rutledge, H Oh, T Wyss-Coray - Nature Reviews Genetics, 2022 - nature.com
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …
related diseases and increase healthspan have suggested targeting the ageing process …
Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality
Biological aging of human organ systems reflects the interplay of age, chronic disease,
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …
DunedinPACE, a DNA methylation biomarker of the pace of aging
Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …
Facing up to the global challenges of ageing
L Partridge, J Deelen, PE Slagboom - Nature, 2018 - nature.com
Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …
people experience little ill health, a trait that should be extended to the general population …
Measuring population ageing: an analysis of the Global Burden of Disease Study 2017
Background Traditional metrics for population health ageing tend not to differentiate
between extending life expectancy and adding healthy years. A population ageing metric …
between extending life expectancy and adding healthy years. A population ageing metric …
[HTML][HTML] An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …
generation of epigenetic biomarkers of aging were developed using chronological age as a …
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …
midlife, but the implications of this variation are poorly understood. We tested associations …
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm
Biological aging is the gradual, progressive decline in system integrity that occurs with
advancing chronological age, causing morbidity and disability. Measurements of the pace of …
advancing chronological age, causing morbidity and disability. Measurements of the pace of …