The diverse roles of DNA methylation in mammalian development and disease
MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …
methylation has numerous functions: it is implicated in the repression of transposons and …
Dynamic DNA methylation: In the right place at the right time
The classical model of cytosine DNA methylation (the presence of 5-methylcytosine, 5mC)
regulation depicts this covalent modification as a stable repressive regulator of promoter …
regulation depicts this covalent modification as a stable repressive regulator of promoter …
[HTML][HTML] Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation
S Kaluscha, S Domcke, C Wirbelauer, MB Stadler… - Nature …, 2022 - nature.com
Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
[PDF][PDF] Activity-regulated transcription: bridging the gap between neural activity and behavior
EL Yap, ME Greenberg - Neuron, 2018 - cell.com
Gene transcription is the process by which the genetic codes of organisms are read and
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …
[HTML][HTML] DNA methylation atlas of the mouse brain at single-cell resolution
Mammalian brain cells show remarkable diversity in gene expression, anatomy and
function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …
function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …
Transcription factors as readers and effectors of DNA methylation
Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …
base-pair resolution under various physiological conditions. Many aberrant or differentially …
[PDF][PDF] Epigenomic signatures of neuronal diversity in the mammalian brain
Neuronal diversity is essential for mammalian brain function but poses a challenge to
molecular profiling. To address the need for tools that facilitate cell-type-specific epigenomic …
molecular profiling. To address the need for tools that facilitate cell-type-specific epigenomic …
[HTML][HTML] CpG and non-CpG methylation in epigenetic gene regulation and brain function
HS Jang, WJ Shin, JE Lee, JT Do - Genes, 2017 - mdpi.com
DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …
[HTML][HTML] Single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain
Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …
Disruption of DNA-methylation-dependent long gene repression in Rett syndrome
Disruption of the MECP2 gene leads to Rett syndrome (RTT), a severe neurological disorder
with features of autism. MECP2 encodes a methyl-DNA-binding protein that has been …
with features of autism. MECP2 encodes a methyl-DNA-binding protein that has been …