Delirium, a syndrome characterized by an acute change in attention, awareness and
cognition, is caused by a medical condition that cannot be better explained by a pre-existing …

Delirium is the most common manifestation of brain dysfunction in critically ill patients. In the
intensive care unit (ICU), duration of delirium is independently predictive of excess death …

Background Invasive mechanical ventilation in critically ill adults involves adjusting the
fraction of inspired oxygen to maintain arterial oxygen saturation. The oxygen-saturation …

Background Current management practices and outcomes in weaning from invasive
mechanical ventilation are poorly understood. We aimed to describe the epidemiology …

Abstract Acute Respiratory Distress Syndrome (ARDS) is one of the most demanding
conditions in an Intensive Care Unit (ICU). Management of analgesia and sedation in ARDS …

Background Patients who have received mechanical ventilation can have prolonged
cognitive impairment for which there is no known treatment. We aimed to establish whether …

Background It is speculated that opioid-free anesthesia may provide adequate pain control
while reducing postoperative opioid consumption. However, there is currently no evidence …

Conventional gabaminergic sedatives such as benzodiazepines and propofol are commonly
used in mechanically ventilated patients in the intensive care unit (ICU). Dexmedetomidine …

Background Postoperative delirium is a frequent event after cardiac surgery. This meta-
analysis aimed to identify relevant risk factors. Method In this meta-analysis, all original …

Septic-associated encephalopathy (SAE) is a key manifestation of sepsis, ranging from
delirium to coma and occurring in up to 70% of patients admitted to the ICU. SAE is …