LSD1: more than demethylation of histone lysine residues
Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …
Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
KK Deeb, DL Trump, CS Johnson - Nature reviews cancer, 2007 - nature.com
Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role
in various human cancers. Preclinical research indicates that the active metabolite of vitamin …
in various human cancers. Preclinical research indicates that the active metabolite of vitamin …
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA
Mammalian genomes are populated with thousands of transcriptional enhancers that
orchestrate cell-type-specific gene expression programs,,,, but how those enhancers are …
orchestrate cell-type-specific gene expression programs,,,, but how those enhancers are …
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
Using a mouse model of human MLL-AF9 leukemia, we identified the lysine-specific
demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) …
demethylase KDM1A (LSD1 or AOF2) as an essential regulator of leukemia stem cell (LSC) …
LSD1 activates a lethal prostate cancer gene network independently of its demethylase function
A Sehrawat, L Gao, Y Wang… - Proceedings of the …, 2018 - National Acad Sciences
Medical castration that interferes with androgen receptor (AR) function is the principal
treatment for advanced prostate cancer. However, clinical progression is universal, and …
treatment for advanced prostate cancer. However, clinical progression is universal, and …
Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade
Y Qin, SN Vasilatos, L Chen, H Wu, Z Cao, Y Fu… - Oncogene, 2019 - nature.com
Immunotherapy strategies have been emerging as powerful weapons against cancer. Early
clinical trials reveal that overall response to immunotherapy is low in breast cancer patients …
clinical trials reveal that overall response to immunotherapy is low in breast cancer patients …
Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1
Androgen receptor (AR) is reactivated in castration-resistant prostate cancer (CRPC)
through mechanisms including marked increases in AR gene expression. We identify an …
through mechanisms including marked increases in AR gene expression. We identify an …
Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis
The metabolic functions of androgen receptor (AR) in normal prostate are circumvented in
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …
Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4
M Vermeulen, KW Mulder, S Denissov… - Cell, 2007 - cell.com
Trimethylation of histone H3 at lysine 4 (H3K4me3) is regarded as a hallmark of active
human promoters, but it remains unclear how this posttranslational modification links to …
human promoters, but it remains unclear how this posttranslational modification links to …