Controversies and evolving new mechanisms in subarachnoid hemorrhage

S Chen, H Feng, P Sherchan, D Klebe, G Zhao… - Progress in …, 2014 - Elsevier
Despite decades of study, subarachnoid hemorrhage (SAH) continues to be a serious and
significant health problem in the United States and worldwide. The mechanisms contributing …

Inflammation and oxidative stress: potential targets for improving prognosis after subarachnoid hemorrhage

F Wu, Z Liu, G Li, L Zhou, K Huang, Z Wu… - Frontiers in cellular …, 2021 - frontiersin.org
Subarachnoid hemorrhage (SAH) has a high mortality rate and causes long-term disability
in many patients, often associated with cognitive impairment. However, the pathogenesis of …

Neuroinflammation and microvascular dysfunction after experimental subarachnoid hemorrhage: emerging components of early brain injury related to outcome

JR Geraghty, JL Davis, FD Testai - Neurocritical care, 2019 - Springer
Aneurysmal subarachnoid hemorrhage has a high mortality rate and, for those who survive
this devastating injury, can lead to lifelong impairment. Clinical trials have demonstrated that …

Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits

XK Tong, C Lecrux, E Hamel - Journal of neuroscience, 2012 - Soc Neuroscience
Alzheimer's disease (AD) is now established as a progressive compromise not only of the
neurons but also of the cerebral vasculature. Increasing evidence also indicates that …

[HTML][HTML] Subarachnoid hemorrhage and cerebral vasospasm–literature review

AV Ciurea, C Palade, D Voinescu… - Journal of medicine and …, 2013 - ncbi.nlm.nih.gov
Subarachnoid hemorrhage represents a serious disease with high mortality and morbidity.
Two important areas are becoming the central research interest of subarachnoid …

Role of endothelial nitric oxide synthase for early brain injury after subarachnoid hemorrhage in mice

IJ Lenz, N Plesnila, NA Terpolilli - Journal of Cerebral Blood …, 2021 - journals.sagepub.com
The first few hours and days after subarachnoid hemorrhage (SAH) are characterized by
cerebral ischemia, spasms of pial arterioles, and a significant reduction of cerebral …

Real-world data of clazosentan in combination therapy for aneurysmal subarachnoid hemorrhage: A multicenter retrospective cohort study

S Muraoka, T Asai, T Fukui, S Ota, S Shimato… - Neurosurgical …, 2023 - Springer
Aneurysmal subarachnoid hemorrhage (aSAH) may lead to cerebral vasospasm,
significantly associated with morbidity and mortality. In double-blind, placebo-controlled …

The role of inflammatory response in stroke associated programmed cell death

K Duris, Z Splichal, M Jurajda - Current neuropharmacology, 2018 - ingentaconnect.com
Stroke represents devastating pathology which is associated with a high morbidity and
mortality. Initial damage caused directly by the onset of stroke, primary injury, may be …

Atorvastatin ameliorates cerebral vasospasm and early brain injury after subarachnoid hemorrhage and inhibits caspase-dependent apoptosis pathway

G Cheng, L Wei, S Zhi-Dan, Z Shi-Guang… - BMC neuroscience, 2009 - Springer
Backgroud Cerebral vasospasm (CVS) and early brain injury remain major causes of
morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH) …

Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage

H Jeon, J Ai, M Sabri, A Tariq, X Shang, G Chen… - BMC neuroscience, 2009 - Springer
About 50% of humans with aneurysmal subarachnoid hemorrhage (SAH) die and many
survivors have neurological and neurobehavioral dysfunction. Animal studies usually …