Bacteria are continuously exposed to numerous endogenous and exogenous DNA-
damaging agents. To maintain genome integrity and ensure cell survival, bacteria have …

How to adapt to a changing environment is a fundamental, recurrent problem confronting
cells. One solution is for cells to organize their constituents into a limited number of spatially …

During meiosis, crossover recombination connects homologous chromosomes to direct their
accurate segregation. Defective crossing over causes infertility, miscarriage and congenital …

DNA mismatch repair (MMR) corrects non-Watson-Crick basepairs generated by replication
errors, recombination intermediates, and some forms of chemical damage to DNA. In MutS …

DNA mismatch repair (MMR) requires coordinated sequential actions of multiple proteins
during a window of time after the replication apparatus makes an error and before the newly …

G-quadruplexes (G4s) are a unique class of noncanonical DNAs that play a key role in
cellular processes and neoplastic transformation. Herein, we focused on the promoter …

Eukaryotic MutLα (mammalian MLH1–PMS2 heterodimer; MLH1–PMS1 in yeast) functions
in early steps of mismatch repair as a latent endonuclease that requires a mismatch …

Proliferating cell nuclear antigen (PCNA) is a homo-trimeric clamp complex that serves as
the molecular hub for various DNA transactions, including DNA synthesis and post …

Research on Escherichia coli DNA replication paved the groundwork for many breakthrough
discoveries with important implications for our understanding of human molecular biology …

Sliding clamps play a pivotal role in the process of replication by increasing the processivity
of the replicative polymerase. They also serve as an interacting platform for a plethora of …