It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and
differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at …

Prion-like RNA binding proteins (RBPs) such as TDP43 and FUS are largely soluble in the
nucleus but form solid pathological aggregates when mislocalized to the cytoplasm. What …

The cell nucleus must continually resist and respond to intercellular and intracellular
mechanical forces to transduce mechanical signals and maintain proper genome …

Nuclear shape and architecture influence gene localization, mechanotransduction,
transcription, and cell function. Abnormal nuclear morphology and protrusions termed …

Cells sense mechanical signals from their microenvironment and transduce them to the
nucleus to regulate gene expression programs. To elucidate the physical mechanisms …

Neutrophilic granulocytes are able to release their own DNA as neutrophil extracellular traps
(NETs) to capture and eliminate pathogens. DNA expulsion (NETosis) has also been …

Biological cells are well known to respond to a multitude of chemical signals. In the nervous
system, chemical signaling has been shown to be crucially involved in development, normal …

Fibroblasts exhibit heterogeneous cell geometries in tissues and integrate both mechanical
and biochemical signals in their local microenvironment to regulate genomic programs via …

ATR controls chromosome integrity and chromatin dynamics. We have previously shown
that yeast Mec1/ATR promotes chromatin detachment from the nuclear envelope to …