Inhibition and induction of human cytochrome P450 enzymes: current status
Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …
Physiologically-based pharmacokinetics in drug development and regulatory science
M Rowland, C Peck, G Tucker - Annual review of pharmacology …, 2011 - annualreviews.org
The application of physiologically-based pharmacokinetic (PBPK) modeling is coming of
age in drug development and regulation, reflecting significant advances over the past 10 …
age in drug development and regulation, reflecting significant advances over the past 10 …
[HTML][HTML] Disease-drug and drug-drug interaction in COVID-19: Risk and assessment
COVID-19 is announced as a global pandemic in 2020. Its mortality and morbidity rate are
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …
Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions
RS Obach, RL Walsky, K Venkatakrishnan - Drug metabolism and …, 2007 - ASPET
The ability to use vitro inactivation kinetic parameters in scaling to in vivo drug-drug
interactions (DDIs) for mechanism-based inactivators of human cytochrome P450 (P450) …
interactions (DDIs) for mechanism-based inactivators of human cytochrome P450 (P450) …
Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring
Abstract Cytochrome P450 (CYP) 3A4 is the most abundant enzyme of CYPs in the liver and
gut that metabolizes approximately 50% currently available drugs. A number of important …
gut that metabolizes approximately 50% currently available drugs. A number of important …
Mechanisms underlying food–drug interactions: inhibition of intestinal metabolism and transport
CS Won, NH Oberlies, MF Paine - Pharmacology & therapeutics, 2012 - Elsevier
Food–drug interaction studies are critical to evaluate appropriate dosing, timing, and
formulation of new drug candidates. These interactions often reflect prandial-associated …
formulation of new drug candidates. These interactions often reflect prandial-associated …
Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions
J Yang, M Liao, M Shou, M Jamei… - Current drug …, 2008 - ingentaconnect.com
In vivo enzyme levels are governed by the rates of de novo enzyme synthesis and
degradation. A current lack of consensus on values of the in vivo turnover half-lives of …
degradation. A current lack of consensus on values of the in vivo turnover half-lives of …
Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of …
OA Fahmi, S Hurst, D Plowchalk, J Cook, F Guo… - Drug Metabolism and …, 2009 - ASPET
Cytochrome P450 3A4 (CYP3A4) is the most important enzyme in drug metabolism and
because it is the most frequent target for pharmacokinetic drug-drug interactions (DDIs) it is …
because it is the most frequent target for pharmacokinetic drug-drug interactions (DDIs) it is …
In Vitro Evaluation of Reversible and Irreversible Cytochrome P450 Inhibition: Current Status on Methodologies and their Utility for Predicting Drug–Drug Interactions
S Fowler, H Zhang - The AAPS journal, 2008 - Springer
It is widely accepted that today's practice of polypharmacy inevitably increases the incidence
of drug–drug interactions (DDIs). Serious DDI is a major liability for any new chemical entity …
of drug–drug interactions (DDIs). Serious DDI is a major liability for any new chemical entity …
Drugs as CYP3A probes, inducers, and inhibitors
YT Liu, HP Hao, CX Liu, GJ Wang… - Drug metabolism …, 2007 - Taylor & Francis
Human cytochrome P450 (CYP) 3A subfamily members (mainly CYP3A4 and CYP3A5)
mediate the metabolism of approximately half all marketed drugs and thus play a critical role …
mediate the metabolism of approximately half all marketed drugs and thus play a critical role …