Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

The hexosamine biosynthetic pathway (HBP) produces uridine diphosphate N-
acetylglucosamine (UDP-GlcNAc) to facilitate O-linked GlcNAc (O-GlcNAc) protein …

The hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-
acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) …

Cardiovascular diseases are known to be the most fatal diseases worldwide.
Ischaemia/reperfusion (I/R) injury is at the centre of the pathology of the most common …

The enzymes of O-GlcNAc cycling couple the nutrient-dependent synthesis of UDP-GlcNAc
to O-GlcNAc modification of Ser/Thr residues of key nuclear and cytoplasmic targets. This …

The modification of nuclear, mitochondrial, and cytosolic proteins by O-linked βN-
acetylglucosamine (O-GlcNAc) has emerged as a dynamic and essential post-translational …

Rationale: Diabetic hyperglycemia is associated with cardiac dysfunction and increased
arrhythmia risk, and CaMKII (calcium/calmodulin-dependent protein kinase II) function has …

The development of the foetal heart is driven by increased glucose uptake and activation of
mammalian target of rapamycin (mTOR) and hypoxia‐inducible factor‐1α (HIF‐1α), which …

The outer mitochondrial membrane GTPase mitofusin 2 (Mfn2) is known to regulate
endoplasmic reticulum (ER) shape in addition to its mitochondrial fusion effects. However, its …