Biological role of unsaturated fatty acid desaturases in health and disease
A Czumaj, T Śledziński - Nutrients, 2020 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are considered one of the most important components
of cells that influence normal development and function of many organisms, both eukaryotes …
of cells that influence normal development and function of many organisms, both eukaryotes …
Recent advances in understanding the genetic architecture of type 2 diabetes
Genome-wide association (GWAS) and sequencing studies are providing new insights into
the genetic basis of type 2 diabetes (T2D) and the inter-individual variation in glycemic traits …
the genetic basis of type 2 diabetes (T2D) and the inter-individual variation in glycemic traits …
The trans-ancestral genomic architecture of glycemic traits
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic
health. To date, most genetic studies of glycemic traits have focused on individuals of …
health. To date, most genetic studies of glycemic traits have focused on individuals of …
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta …
Background Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and
assess glycemic control in patients with diabetes. Previous genome-wide association …
assess glycemic control in patients with diabetes. Previous genome-wide association …
A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels
Polygenic scores (PGSs) combine the effects of common genetic variants, to predict risk or
treatment strategies for complex diseases,,,–. Adding rare variation to PGSs has largely …
treatment strategies for complex diseases,,,–. Adding rare variation to PGSs has largely …
A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells
Y Ye, M Barghouth, H Dou, C Luan, Y Wang… - Nature …, 2022 - nature.com
Glucose-induced insulin secretion depends on β-cell electrical activity. Inhibition of ATP-
regulated potassium (KATP) channels is a key event in this process. However, KATP …
regulated potassium (KATP) channels is a key event in this process. However, KATP …
Epigenome-wide association study identifies TXNIP gene associated with type 2 diabetes mellitus and sustained hyperglycemia
C Soriano-Tárraga, J Jiménez-Conde… - Human molecular …, 2016 - academic.oup.com
Type 2 diabetes mellitus (DM) is an established risk factor for a wide range of vascular
diseases, including ischemic stroke (IS). Glycated hemoglobin A1c (HbA1c), a marker for …
diseases, including ischemic stroke (IS). Glycated hemoglobin A1c (HbA1c), a marker for …
Cohort profile: the Singapore multi-ethnic cohort (mec) study
KHX Tan, LWL Tan, X Sim, ES Tai… - International journal …, 2018 - academic.oup.com
Non-communicable diseases such as type 2 diabetes (T2D) mellitus, coronary artery
disease, stroke and cancers, are major contributors to ill health across the world including …
disease, stroke and cancers, are major contributors to ill health across the world including …
Potential Clinical Error Arising From Use of HbA1c in Diabetes: Effects of the Glycation Gap
AU Nayak, BM Singh, SJ Dunmore - Endocrine Reviews, 2019 - academic.oup.com
The glycation gap (GGap) and the similar hemoglobin glycation index (HGI) define
consistent differences between glycated hemoglobin and actual glycemia derived from …
consistent differences between glycated hemoglobin and actual glycemia derived from …
Are There Clinical Implications of Racial Differences in HbA1c? Yes, to Not Consider Can Do Great Harm!
WH Herman - Diabetes Care, 2016 - Am Diabetes Assoc
Studies that have compared HbA1c levels by race have consistently demonstrated higher
HbA1c levels in African Americans than in whites. These racial differences in HbA1c have …
HbA1c levels in African Americans than in whites. These racial differences in HbA1c have …