How do CARs work? Early insights from recent clinical studies targeting CD19

ML Davila, R Brentjens, X Wang, I Rivière… - …, 2012 - Taylor & Francis
Second-generation chimeric antigen receptors (CARs) are powerful tools to redirect antigen-
specific T cells independently of HLA-restriction. Recent clinical studies evaluating CD19 …

Rituximab, ofatumumab and other monoclonal anti‐CD20 antibodies for chronic lymphocytic leukaemia

K Bauer, M Rancea, V Roloff, T Elter… - Cochrane Database …, 2012 - cochranelibrary.com
Background Chronic lymphocytic leukaemia (CLL) accounts for 25% of all leukaemias and
is the most common lymphoid malignancy in western countries. Standard treatments include …

Guidelines on the diagnosis, investigation and management of chronic lymphocytic leukaemia.

D Oscier, C Dearden, E Erem… - British journal of …, 2012 - search.ebscohost.com
The article provides information on diagnosis and management of chronic lymphocytic
leukemia (CLL). It informs about diagnosis of the CLL which includes lymphocyte …

Phase II study of lenalidomide and rituximab as salvage therapy for patients with relapsed or refractory chronic lymphocytic leukemia

XC Badoux, MJ Keating, S Wen, WG Wierda… - Journal of Clinical …, 2013 - ascopubs.org
Purpose Lenalidomide is an immunomodulatory drug active as salvage therapy for chronic
lymphocytic leukemia (CLL). We combined lenalidomide with rituximab to improve response …

Bendamustine and rituximab in relapsed and refractory hairy cell leukemia

M Burotto, M Stetler-Stevenson, E Arons, H Zhou… - Clinical Cancer …, 2013 - AACR
Purpose: To determine tolerability and for the first time explore efficacy of bendamustine–
rituximab (BR) in multiply relapsed/refractory hairy cell leukemia (HCL), using two different …

Managing Ibrutinib-Intolerant Patients With B-Cell Malignancies

J Muñoz, S Sarosiek, JJ Castillo - The Oncologist, 2023 - academic.oup.com
Ibrutinib is a first-generation inhibitor of Bruton tyrosine kinase (BTK) that is currently
approved to treat patients with B-cell malignancies, including Waldenström …

[HTML][HTML] Combination of bendamustine and rituximab as front-line therapy for patients with chronic lymphocytic leukaemia: multicenter, retrospective clinical practice …

M Gentile, K Zirlik, S Ciolli, FR Mauro… - European Journal of …, 2016 - Elsevier
Recently, encouraging results in terms of safety and efficacy have been obtained using
bendamustine–rituximab (BR) in untreated chronic lymphocytic leukaemia (CLL) patients …

The role of antibody-based therapies in treating relapsed chronic lymphocytic leukemia

M Witkowska, A Majchrzak, P Robak… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Chronic lymphocytic leukemia (CLL) is one of the most common types of
leukemia in adult patients. The landscape of CLL therapy has changed in the last decades …

Safety and efficacy of different lenalidomide starting doses in patients with relapsed or refractory chronic lymphocytic leukemia: results of an international multicenter …

CM Wendtner, M Hallek, GAM Fraser… - Leukemia & …, 2016 - Taylor & Francis
The objective of this study was to evaluate the safety and efficacy of different lenalidomide
starting doses in patients with relapsed/refractory chronic lymphocytic leukemia (CLL). CLL …

Retreatment with bendamustine-containing regimens in patients with relapsed/refractory chronic lymphocytic leukemia and indolent B-cell lymphomas achieves high …

R Weide, S Feiten, V Friesenhahn… - Leukemia & …, 2013 - Taylor & Francis
Bendamustine and bendamustine/rituximab combinations have shown high efficacy in
relapsed/refractory chronic lymphocytic leukemia (CLL) and indolent B-cell malignancies …