The generation of amyloid β-peptide (Aβ) by enzymatic cleavages of the β-amyloid
precursor protein (APP) has been at the center of Alzheimer's disease (AD) research. While …

The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and
EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels …

Presenilin mutations that alter γ-secretase activity cause familial Alzheimer's disease (AD),
whereas ApoE4, an apolipoprotein for cholesterol transport, predisposes to sporadic AD …

The induced pluripotent stem (iPS) cell field holds promise for in vitro disease modeling.
However, identifying innate cellular pathologies, particularly for age-related …

Fibrosis is the major determinant of morbidity and mortality in patients with nonalcoholic
steatohepatitis (NASH) but has no approved pharmacotherapy in part because of …

J. Neurochem.(2012) 120 (Suppl. 1), 9–21. Abstract β‐Amyloid precursor protein (APP) is a
critical factor in the pathogenesis of Alzheimer's disease (AD). APP undergoes post …

Presenilins play essential roles in memory formation, synaptic function, and neuronal
survival. Mutations in the Presenilin-1 (PSEN1) gene are the major cause of familial …

Despite the progress of the past two decades, the cause of Alzheimer's disease (AD) and
effective treatments against it remain elusive. The hypothesis that amyloid-β (Aβ) peptides …

One of the most critical pathological features of Alzheimer's disease (AD) is the
accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for the
most cases of dementia, which is characterized by the deposition of dense plaques of …