The kindlin (or fermitin) family of proteins comprises three members (kindlin-1,-2 and-3) of
evolutionarily conserved focal adhesion (FA) proteins, whose best-known task is to increase …

Background Inherited epidermolysis bullosa (EB) comprises a highly heterogeneous group
of rare diseases characterized by exacerbated skin and/or mucosal fragility and blister …

Mutations in the FERMT1 gene (also known as KIND1), encoding the focal adhesion protein
kindlin‐1, underlie the Kindler syndrome (KS), an autosomal recessive skin disorder with an …

Kindlin-1 is an integrin tail binding protein that controls integrin activation. Mutations in the
FERMT-1 gene, which encodes for Kindlin-1, lead to Kindler syndrome in man, which is …

Kindler syndrome (OMIM 173650) is an autosomal recessive genodermatosis characterized
by trauma‐induced blistering, poikiloderma, skin atrophy, mucosal inflammation and varying …

Understanding of blistering skin disorders involving the dermal-epidermal junction (DEJ)
has improved considerably over the past 2 decades. This has been possible with the …

The kindlins represent a class of focal adhesion proteins implicated in integrin activation.
They comprise three evolutionarily conserved members, kindlin-1, kindlin-2 and kindlin-3 …

Kindling the flame of integrin activation and function with... : Current Opinion in Hematology
Kindling the flame of integrin activation and function with kindlins : Current Opinion in …

Kindler syndrome (KS) results from pathogenic loss-of-function mutations in the KIND1
gene, which encodes kindlin-1, a focal adhesion and actin cytoskeleton-related protein. How …

Abstract Background Kindler Syndrome (KS) is a rare genodermatosis characterized by skin
fragility, skin atrophy, premature aging and poikiloderma. It is caused by mutations in the …