Protein aggregation is one of the key challenges in the development of protein
biotherapeutics. It is a critical product quality issue as well as a potential safety concern due …

Introduction Liposomes have been used as carriers for vaccine adjuvants and antigens due
to their inherent biocompatibility and versatility as delivery vehicles. Two vial admixture of …

Nanotechnology-based strategies can dramatically impact the treatment, prevention and
diagnosis of a wide range of diseases. Despite the unprecedented success achieved with …

The advent of mass vaccination has saved millions of human lives and revolutionized the
quality of life. Vaccination is currently one of the most cost effective ways of managing …

The number of patients suffering from allergic asthma and rhinoconjunctivitis has increased
dramatically within the last decades. Allergen‐specific immunotherapy (AIT) is the only …

Liver-targeting nanoparticles have emerged as a promising platform for the induction of
immune tolerance by taking advantage of the liver's unique tolerogenic properties and …

Introduction For several years now, medicine has been benefiting from the contribution of
nanoparticles (NPs) technology for both diagnosis and therapy. They can be used as …

B-1 lymphocytes comprise a unique subset of B cells that differ phenotypically,
ontogenetically and functionally from conventional B-2 cells. A frequent specificity of the …

Liposome–protamine–DNA nanoparticles (LPD) are safe, effective, and non-toxic adjuvants
that induce Th1-like immune responses. We hypothesized that encapsulation of allergens …

Atopic asthma in childhood with the tendency to persist into adult life is an important issue in
pediatrics. Allergen-specific immunotherapy (SIT) is the only curative treatment option for …