Abstract l-asparaginase (EC 3.5. 1.1) is an important enzyme that has been purified and characterized for over decades to study and evaluate its anti-carcinogenic activity against …
Abstract l-asparaginase (l-asparagine amino hydrolase, EC 3.5. 1.1) is an enzyme clinically accepted as an antitumor agent to treat acute lymphoblastic leukemia and lymphosarcoma …
PR Krishnapura, PD Belur… - Critical reviews in …, 2016 - Taylor & Francis
Abstract l-Asparaginase is one of the main drugs used in the treatment of acute lymphoblastic leukemia (ALL), a commonly diagnosed pediatric cancer. Although several …
M Monajati, S Borandeh, A Hesami, D Mansouri… - Chemical Engineering …, 2018 - Elsevier
There is an increasing interest in using l-asparaginase in medical fields and food processing industries. Enzyme immobilization is an attractive field to improve l-asparaginase activity …
Asparaginase is an important antileukemic agent extensively used worldwide but the intrinsic glutaminase activity of this enzymatic drug is responsible for serious life threatening …
Enzymes today play a predominant role in the pharmaceutical industries due to their ability to efficiently and selectively catalyze biochemical reactions in living systems. Since the …
H Saeed, A Hemida, N El-Nikhely… - International journal of …, 2020 - Elsevier
Abstract L-Asparaginase (L-ASNase EC 3.5. 1.1) is considered as an important biopharmaceutical drug enzyme in the treatment of childhood acute lymphoblastic leukemia …
Background L-asparaginase (ASNase) has played a key role in the management of acute lymphoblastic leukaemia (ALL). As an amidohydrolase, it catalyzes the hydrolysis of L …
A Ulu, B Ates - Bioconjugate chemistry, 2017 - ACS Publications
There are two major applications of l-asparaginase (L-ASNase): leukemia therapy and the food industry. Especially, its chemotherapeutic effect has attracted interest from the scientific …