Development of L-asparaginase biobetters: current research status and review of the desirable quality profiles

LP Brumano, FVS da Silva, TA Costa-Silva… - … in bioengineering and …, 2019 - frontiersin.org
L-Asparaginase (ASNase) is a vital component of the first line treatment of acute
lymphoblastic leukemia (ALL), an aggressive type of blood cancer expected to afflict over …

Microbial l-asparaginase: purification, characterization and applications

F Muneer, MH Siddique, F Azeem, I Rasul… - Archives of …, 2020 - Springer
Abstract l-asparaginase (EC 3.5. 1.1) is an important enzyme that has been purified and
characterized for over decades to study and evaluate its anti-carcinogenic activity against …

Therapeutic l-asparaginase: upstream, downstream and beyond

AM Lopes, L Oliveira-Nascimento… - Critical reviews in …, 2017 - Taylor & Francis
Abstract l-asparaginase (l-asparagine amino hydrolase, EC 3.5. 1.1) is an enzyme clinically
accepted as an antitumor agent to treat acute lymphoblastic leukemia and lymphosarcoma …

A critical review on properties and applications of microbial l-asparaginases

PR Krishnapura, PD Belur… - Critical reviews in …, 2016 - Taylor & Francis
Abstract l-Asparaginase is one of the main drugs used in the treatment of acute
lymphoblastic leukemia (ALL), a commonly diagnosed pediatric cancer. Although several …

Immobilization of L-asparaginase on aspartic acid functionalized graphene oxide nanosheet: enzyme kinetics and stability studies

M Monajati, S Borandeh, A Hesami, D Mansouri… - Chemical Engineering …, 2018 - Elsevier
There is an increasing interest in using l-asparaginase in medical fields and food processing
industries. Enzyme immobilization is an attractive field to improve l-asparaginase activity …

Purification and Characterization of Glutaminase Free Asparaginase from Enterobacter cloacae: In-Vitro Evaluation of Cytotoxic Potential against Human Myeloid …

I Husain, A Sharma, S Kumar, F Malik - PLoS One, 2016 - journals.plos.org
Asparaginase is an important antileukemic agent extensively used worldwide but the
intrinsic glutaminase activity of this enzymatic drug is responsible for serious life threatening …

Therapeutic enzymes: discoveries, production and applications

S Tandon, A Sharma, S Singh, S Sharma… - Journal of Drug Delivery …, 2021 - Elsevier
Enzymes today play a predominant role in the pharmaceutical industries due to their ability
to efficiently and selectively catalyze biochemical reactions in living systems. Since the …

Highly efficient Pyrococcus furiosus recombinant L-asparaginase with no glutaminase activity: Expression, purification, functional characterization, and cytotoxicity on …

H Saeed, A Hemida, N El-Nikhely… - International journal of …, 2020 - Elsevier
Abstract L-Asparaginase (L-ASNase EC 3.5. 1.1) is considered as an important
biopharmaceutical drug enzyme in the treatment of childhood acute lymphoblastic leukemia …

Towards development of biobetter: L-asparaginase a case study

RK Tripathy, J Anakha, AH Pande - Biochimica et Biophysica Acta (BBA) …, 2024 - Elsevier
Background L-asparaginase (ASNase) has played a key role in the management of acute
lymphoblastic leukaemia (ALL). As an amidohydrolase, it catalyzes the hydrolysis of L …

Immobilization of l-Asparaginase on Carrier Materials: A Comprehensive Review

A Ulu, B Ates - Bioconjugate chemistry, 2017 - ACS Publications
There are two major applications of l-asparaginase (L-ASNase): leukemia therapy and the
food industry. Especially, its chemotherapeutic effect has attracted interest from the scientific …