Pediatric brain tumors are the most common solid malignancies in children. Advances in the
treatment of pediatric brain tumors have come in the form of imaging, biopsy, surgical …

Multiple endocrine neoplasia type 1 (MEN1), an autosomal-dominantly inherited tumor
syndrome, is classically defined by tumors arising from the “3 Ps”: Parathyroids, Pituitary …

The 5th edition of World Health Organization (WHO) Central Nervous System (CNS) tumours
classification has transformed the pathological diagnosis of gliomas from purely histological …

Background Intracranial extraventricular ependymoma (IEE) is an ependymoma located in
the brain parenchyma outside the ventricles. IEE has overlapping clinical and imaging …

The treatment of childhood solid cancer has markedly evolved in recent years following a
refined molecular characterization and the introduction of novel targeted drugs. On one …

The study of genetic alterations and molecular biology in central nervous system (CNS)
tumors has improved the accuracy of estimations of patient prognosis and tumor …

The ubiquitin proteasome system (UPS) is critically important for cellular homeostasis and
affects virtually all key functions in normal and neoplastic cells. Currently, a comprehensive …

Simple Summary Tumours of the central nervous system (CNS) are the most common solid
tumours in children. The difficulties in treating this complicated variety of tumours are that …

The challenges in identifying effective therapies for CNS tumors continue to be daunting.
Potentially effective targeted therapies must be able to penetrate the blood–brain barrier to …

Purpose To investigate the predictive value of the “soap bubble” sign on molecular subtypes
(Group A [PFA] and Group B [PFB]) of posterior fossa ependymomas (PF-EPNs). Methods …