The blood-testis barrier and its implications for male contraception
CY Cheng, DD Mruk, DR Sibley - Pharmacological reviews, 2012 - Elsevier
The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian
body. It divides the seminiferous epithelium into the basal and the apical (adluminal) …
body. It divides the seminiferous epithelium into the basal and the apical (adluminal) …
A family of drug transporters: the multidrug resistance-associated proteins
The human multidrug resistance-associated protein (MRP) family currently has seven
members. The ability of several of these membrane proteins to transport a wide range of …
members. The ability of several of these membrane proteins to transport a wide range of …
Resistance mechanisms associated with altered intracellular distribution of anticancer agents
AK Larsen, AE Escargueil, A Skladanowski - Pharmacology & therapeutics, 2000 - Elsevier
The resistance of tumor cells to anticancer agents remains a major cause of treatment failure
in cancer patients. The term multidrug resistance (MDR) is used to define a resistance …
in cancer patients. The term multidrug resistance (MDR) is used to define a resistance …
[PDF][PDF] Physiology and pharmacological role of the blood-brain barrier
J Bernacki, A Dobrowolska, K Nierwiñska, A Malecki - Pharmacol rep, 2008 - Citeseer
The central nervous system (CNS) is a perfectly regulated environment with conditions far
different from those in the rest of the organism. Even slight changes in this machinery affect …
different from those in the rest of the organism. Even slight changes in this machinery affect …
The blood–brain barrier in neurodegenerative disease: a rhetorical perspective
PM Carvey, B Hendey… - Journal of …, 2009 - Wiley Online Library
Recent studies suggest that the function of the blood–brain barrier (BBB) is not static under
normal physiologic conditions and is likely altered in neurodegenerative disease. Prevailing …
normal physiologic conditions and is likely altered in neurodegenerative disease. Prevailing …
Potential role of drug transporters in the pathogenesis of medically intractable epilepsy
P Kwan, MJ Brodie - Epilepsia, 2005 - Wiley Online Library
The pathogenesis underlying pharmacoresistance in epilepsy is unclear. One of the
candidate mechanisms that has attracted growing interest is the limitation of antiepileptic …
candidate mechanisms that has attracted growing interest is the limitation of antiepileptic …
Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters
The 190 kDa multidrug resistance protein 1 (MRP1/ABCC1) is a founding member of a
subfamily of the ATP binding cassette (ABC) superfamily of transport proteins and was …
subfamily of the ATP binding cassette (ABC) superfamily of transport proteins and was …
Role of the hypothalamic-pituitary-adrenal axis, glucocorticoids and glucocorticoid receptors in toxic sequelae of exposure to bacterial and viral products
JI Webster, EM Sternberg - Journal of Endocrinology, 2004 - joe.bioscientifica.com
The present study was undertaken to investigate heat stress protein (HSP)-70 mRNA
induction and p38 MAP kinase (MAPK) activity in response to ischaemic stress in the …
induction and p38 MAP kinase (MAPK) activity in response to ischaemic stress in the …
Drug transporters, the blood–testis barrier, and spermatogenesis
L Su, DD Mruk, CY Cheng - The Journal of endocrinology, 2010 - pmc.ncbi.nlm.nih.gov
The blood–testis barrier (BTB), which is created by adjacent Sertoli cells near the basement
membrane, serves as a 'gatekeeper'to prohibit harmful substances from reaching …
membrane, serves as a 'gatekeeper'to prohibit harmful substances from reaching …