Intestinal colonization resistance in the context of environmental, host, and microbial determinants
Microbial communities that colonize the human gastrointestinal (GI) tract defend against
pathogens through a mechanism known as colonization resistance (CR). Advances in …
pathogens through a mechanism known as colonization resistance (CR). Advances in …
Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens
K Jones, CB de Brito, MX Byndloss - Cell Chemical Biology, 2025 - cell.com
A widely recognized benefit of gut microbiota is that it provides colonization resistance
against enteric pathogens. The gut microbiota and their products can protect the host from …
against enteric pathogens. The gut microbiota and their products can protect the host from …
Microbially catalyzed conjugation of GABA and tyramine to bile acids
Bile acids (BAs) are cholesterol-derived molecules that aid in digestion and nutrient
absorption, regulate host metabolic processes, and influence physiology of the gut …
absorption, regulate host metabolic processes, and influence physiology of the gut …
Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway
Q Nie, X Luo, K Wang, Y Ding, S Jia, Q Zhao, M Li… - Cell, 2024 - cell.com
The gut microbiota has been found to play an important role in the progression of metabolic
dysfunction-associated steatohepatitis (MASH), but the mechanisms have not been …
dysfunction-associated steatohepatitis (MASH), but the mechanisms have not been …
Loss of Bacteroides thetaiotaomicron bile acid-altering enzymes impacts bacterial fitness and the global metabolic transcriptome
Bacteroides thetaiotaomicron (B. theta) is a Gram-negative gut bacterium that encodes
enzymes that alter the bile acid pool in the gut. Primary bile acids are synthesized by the …
enzymes that alter the bile acid pool in the gut. Primary bile acids are synthesized by the …
Metagenomic, metabolomic, and lipidomic shifts associated with fecal microbiota transplantation for recurrent Clostridioides difficile infection
AS McMillan, G Zhang, MK Dougherty, SK McGill… - Msphere, 2024 - journals.asm.org
Recurrent C. difficile infection (rCDI) is an urgent public health threat, for which the last resort
and lifesaving treatment is a fecal microbiota transplant (FMT). However, the exact …
and lifesaving treatment is a fecal microbiota transplant (FMT). However, the exact …
The microbial-derived bile acid lithocholate and its epimers inhibit Clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota
Clostridioides difficile is a Gram-positive, spore-forming anaerobe that causes clinical
diseases ranging from diarrhea and pseudomembranous colitis to toxic megacolon and …
diseases ranging from diarrhea and pseudomembranous colitis to toxic megacolon and …
Identification of novel fructo-oligosaccharide bacterial consumers by pulse metatranscriptomics in a human stool sample
C Prattico, E Gonzalez, L Dridi, S Jazestani, KE Low… - mSphere, 2024 - journals.asm.org
Dietary fibers influence the composition of the human gut microbiota and directly contribute
to its downstream effects on host health. As more research supports the use of glycans as …
to its downstream effects on host health. As more research supports the use of glycans as …