The plasma membrane of eukaryotic cells is not a simple sheet of lipids and proteins but is
differentiated into subdomains with crucial functions. Caveolae, small pits in the plasma …

Promising targeted treatments and immunotherapy strategies in oncology and
advancements in our understanding of molecular pathways that underpin cancer …

Caveolae are submicroscopic, plasma membrane pits that are abundant in many
mammalian cell types. The past few years have seen a quantum leap in our understanding …

There are many pathways of endocytosis at the cell surface that apparently operate at the
same time. With the advent of new molecular genetic and imaging tools, an understanding of …

Anoikis (or cell-detachment-induced apoptosis) is a self-defense strategy that organisms use
to eliminate 'misplaced'cells, ie cells that are in an inappropriate location. Occasionally …

Mechanotransduction is a key determinant of tissue homeostasis and tumor progression. It is
driven by intercellular adhesions, cell contractility, and forces generated within the …

Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …

Caveolins (Cavs) are integrated plasma membrane proteins that are complex signaling
regulators with numerous partners and whose activity is highly dependent on cellular …

Folate can be transported into the cell by the reduced folate carrier (RFC), the proton-
coupled folate transporter (PCFT), or the folate receptor (FR), of which various isoforms exist …

Cancer fatalities result from metastatic dissemination and therapy resistance, both
processes that depend on signals from the tumor microenvironment. To identify how …