The kruppel-like factor (KLF) family, diseases, and physiological events

K Yuce, AI Ozkan - Gene, 2024 - Elsevier
Abstract The Kruppel-Like Factor family of regulatory proteins, which has 18 members, is
transcription factors. This family contains zinc finger proteins, regulates the activation and …

The roles and regulation of the KLF5 transcription factor in cancers

Y Luo, C Chen - Cancer science, 2021 - Wiley Online Library
Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …

[HTML][HTML] The role of liver sinusoidal endothelial cells in cancer liver metastasis

M Yang, C Zhang - American Journal of Cancer Research, 2021 - ncbi.nlm.nih.gov
Liver sinusoidal endothelial cells (LSECs) are the gatekeeper cells in the liver, contributing
critical roles in liver physiological and pathological changes. Factors such as dietary …

[HTML][HTML] Role of hydrogen sulfide donors in cancer development and progression

EE Ngowi, A Afzal, M Sarfraz, S Khattak… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
In recent years, a vast number of potential cancer therapeutic targets have emerged.
However, developing efficient and effective drugs for the targets is of major concern …

The beclin 1 interactome: Modification and roles in the pathology of autophagy-related disorders

S Kaur, H Changotra - Biochimie, 2020 - Elsevier
Beclin 1 a yeast Atg6/VPS30 orthologue has a significant role in autophagy process
(Macroautophagy) and protein sorting. The function of beclin 1 depends on the interaction …

PRMT5 activates KLF5 by methylation to facilitate lung cancer

H Zhou, J Chang, J Zhang, H Zheng… - Journal of cellular …, 2024 - Wiley Online Library
The highly expressed oncogenic factor Krüppel‐like factor 5 (KLF5) promotes various
cancerous processes, such as cell growth, survival, anti‐apoptosis, migration and …

New insights into KLFs and SOXs in cancer pathogenesis, stemness, and therapy

L Zeng, Y Zhu, CS Moreno, Y Wan - Seminars in cancer biology, 2023 - Elsevier
Despite the development of cancer therapies, the success of most treatments has been
impeded by drug resistance. The crucial role of tumor cell plasticity has emerged recently in …

Participation of Krüppel-like factors in atherogenesis

S Kotlyarov, A Kotlyarova - Metabolites, 2023 - mdpi.com
Atherosclerosis is an important problem in modern medicine, the keys to understanding
many aspects of which are still not available to clinicians. Atherosclerosis develops as a …

Long intergenic noncoding RNA 00908 promotes proliferation and inhibits apoptosis of colorectal cancer cells by regulating KLF5 expression

TD Shan, ZB Tian, Q Li, YP Jiang, FG Liu… - Journal of Cellular …, 2021 - Wiley Online Library
Long intergenic noncoding RNAs (lincRNAs) play a vital role in the occurrence and
progression of cancer. The mechanism of lincRNAs in colorectal cancer (CRC) has not been …

Regulome‐wide association study identifies genetically driven accessible regions associated with pancreatic cancer risk

S Liu, H Zhong, J Zhu, Y Wu, Y Deng… - International Journal of …, 2024 - Wiley Online Library
Genome‐wide association studies (GWAS) have identified two dozen genetic variants that
are associated with the risk of pancreatic ductal adenocarcinoma (PDAC), a deadly …