Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …

Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …

Alpha-synuclein is a protein implicated in Parkinson's disease and thought to be one of the
main pathological drivers in the disease, although it remains unclear how this protein elicits …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy and apoptosis are basic physiologic processes contributing to the maintenance
of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic …

Converging evidence from genetic, pathological and experimental studies have increasingly
suggested an important role for autophagy impairment in Parkinson's Disease (PD). Genetic …

Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …

Background As common, progressive, and chronic causes of disability and death,
neurodegenerative diseases (NDDs) significantly threaten human health, while no effective …