Memory B cells are major targets for effective immunotherapy in relapsing multiple sclerosis

D Baker, M Marta, G Pryce, G Giovannoni… - …, 2017 - thelancet.com
Although multiple sclerosis (MS) is considered to be a CD4, Th17-mediated autoimmune
disease, supportive evidence is perhaps circumstantial, often based on animal studies, and …

Epstein–Barr virus: how its lytic phase contributes to oncogenesis

Q Rosemarie, B Sugden - Microorganisms, 2020 - mdpi.com
Epstein–Barr Virus (EBV) contributes to the development of lymphoid and epithelial
malignancies. While EBV's latent phase is more commonly associated with EBV-associated …

Epstein-Barr virus-related post-transplant lymphoproliferative disease (EBV-PTLD) in the setting of allogeneic stem cell transplantation: a comprehensive review from …

R Al Hamed, AH Bazarbachi, M Mohty - Bone marrow transplantation, 2020 - nature.com
Epstein-Barr virus (EBV) is a ubiquitous herpes virus that infects the majority of the
population worldwide. The virus can establish a lifelong latent infection in host B …

Immune reconstitution post allogeneic transplant and the impact of immune recovery on the risk of infection

RS Mehta, K Rezvani - Virulence, 2016 - Taylor & Francis
Infection is the leading cause of non-relapse mortality after allogeneic haematopoietic cell
transplantation (HCT). This occurs as a result of dysfunction to the host immune system from …

Management of post‐transplant lymphoproliferative disorders

CB DeStefano, SH Desai, AG Shenoy… - British journal of …, 2018 - Wiley Online Library
The post‐transplant lymphoproliferative disorders (PTLD s) are a heterogeneous group of
neoplasms that are one of the most serious complications of bone marrow and solid organ …

Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection

AM Price, J Dai, Q Bazot, L Patel, PA Nikitin… - Elife, 2017 - elifesciences.org
Latent Epstein-Barr virus (EBV) infection is causally linked to several human cancers. EBV
expresses viral oncogenes that promote cell growth and inhibit the apoptotic response to …

The IPTA Nashville Consensus Conference on Post‐Transplant lymphoproliferative disorders after solid organ transplantation in children: III–Consensus guidelines …

J Preiksaitis, U Allen, CM Bollard… - Pediatric …, 2024 - Wiley Online Library
Abstract The International Pediatric Transplant Association convened an expert consensus
conference to assess current evidence and develop recommendations for various aspects of …

Asymptomatic primary infection with Epstein-Barr virus: observations on young adult cases

RJ Abbott, A Pachnio, I Pedroza-Pacheco… - Journal of …, 2017 - Am Soc Microbiol
Epstein-Barr virus (EBV) is typically acquired asymptomatically in childhood. In contrast,
infection later in life often leads to infectious mononucleosis (IM), a febrile illness …

Learning from other autoimmunities to understand targeting of B cells to control multiple sclerosis

D Baker, G Pryce, S Amor, G Giovannoni, K Schmierer - Brain, 2018 - academic.oup.com
Although many suspected autoimmune diseases are thought to be T cell-mediated, the
response to therapy indicates that depletion of B cells consistently inhibits disease activity. In …

From bedside to bench: how existing therapies inform the relationship between Epstein–Barr virus and multiple sclerosis

Z Dyer, D Tscharke, I Sutton… - Clinical & translational …, 2023 - Wiley Online Library
Therapy for relapsing–remitting multiple sclerosis (MS) has advanced dramatically despite
incomplete understanding of the cause of the condition. Current treatment involves inducing …