Lung epithelial cells are increasingly recognized to be active effectors of microbial defense,
contributing to both innate and adaptive immune function in the lower respiratory tract. As …

Biofilms are intricate multicellular structures created by microorganisms on living (biotic) or
nonliving (abiotic) surfaces. Medically, biofilms often lead to persistent infections, increased …

The rising prevalence of antibiotic resistance underscores the urgent need for novel
antimicrobial agents. Antimicrobial peptides (AMPs) are potentially effective therapeutics …

The ability to maintain proper airway surface liquid (ASL) volume homeostasis is vital for
mucus hydration and clearance, which are essential aspects of the mammalian lung's innate …

Antimicrobial peptides (AMPs) are potent antibiotics of the innate immune system that have
been extensively investigated as a potential solution to the global problem of infectious …

Pseudomonas aeruginosa is the most prevalent bacterial species that contribute to cystic
fibrosis (CF) respiratory failure. The impaired function of CF transmembrane conductance …

Suppression of type 17 immunity by type I interferon (IFN) during influenza A infection has
been shown to enhance susceptibility to secondary bacterial pneumonia. Although this …

Polymorphonuclear neutrophils (PMNs) figure prominently in host defense against infection
and in noninfectious inflammation. Mobilized early in an inflammatory response, PMNs …

Pneumonia is initiated by microbes in the lung, but physiological processes integrating
responses across diverse cell types and organ systems dictate the outcome of respiratory …

Many critical biological processes take place at hydrophobic: hydrophilic interfaces, and a
wide range of organisms produce surface-active proteins and peptides that reduce surface …