Mechanisms of Antibiotic Resistance and Developments in Therapeutic Strategies to Combat Klebsiella pneumoniae Infection

Y Li, S Kumar, L Zhang - Infection and Drug Resistance, 2024 - Taylor & Francis
Infections with drug-resistant bacteria have become one of the greatest public health
challenges, and K. pneumoniae is among the top six drug-resistant bacteria. K. pneumoniae …

Antibiotics-free compounds for managing carbapenem-resistant bacteria; a narrative review

A Shariati, M Kashi, Z Chegini… - Frontiers in …, 2024 - frontiersin.org
Carbapenem-resistant (CR) Gram-negative bacteria have become a significant public health
problem in the last decade. In recent years, the prevalence of CR bacteria has increased …

Isolation and characterization of two novel bacteriophages against carbapenem-resistant Klebsiella pneumoniae

A Senhaji-Kacha, M Bernabéu-Gimeno… - Frontiers in cellular …, 2024 - frontiersin.org
The increase of antibiotic-resistant bacteria has become a global health emergency and the
need to explore alternative therapeutic options arises. Phage therapy uses bacteriophages …

Characterization of a Lytic Bacteriophage and Demonstration of Its Combined Lytic Effect with a K2 Depolymerase on the Hypervirulent Klebsiella pneumoniae Strain …

BZ Pertics, T Kovács, G Schneider - Microorganisms, 2023 - mdpi.com
Klebsiella pneumoniae is a nosocomial pathogen. Among its virulence factors is the capsule
with a prominent role in defense and biofilm formation. Bacteriophages (phages) can evoke …

In Vitro Activity, Stability and Molecular Characterization of Eight Potent Bacteriophages Infecting Carbapenem-Resistant Klebsiella pneumoniae

AA Baqer, K Fang, N Mohd-Assaad, SNA Adnan… - Viruses, 2022 - mdpi.com
Background: Members of the genus Klebsiella are among the leading microbial pathogens
associated with nosocomial infection. The increased incidence of antimicrobial resistance in …

Bacteriophage-Resistant Carbapenem-Resistant Klebsiella pneumoniae Shows Reduced Antibiotic Resistance and Virulence

Q Chen, F Zhang, J Bai, Q Che, L Xiang… - International Journal of …, 2024 - Elsevier
Phage therapy has shown great promise in the treatment of bacterial infections. However,
the effectiveness of phage therapy is compromised by the inevitable emergence of phage …

Isolation and identification of a novel phage targeting clinical multidrug-resistant Corynebacterium striatum isolates

J Wang, M Zhang, J Pei, W Yi, L Fan… - Frontiers in Cellular …, 2024 - frontiersin.org
Introduction Over the past decade, Corynebacterium striatum (C. striatum), an emerging
multidrug-resistant (MDR) pathogen, has significantly challenged healthcare settings …

Potential of an Isolated Bacteriophage to Inactivate Klebsiella pneumoniae: Preliminary Studies to Control Urinary Tract Infections

J Duarte, C Máximo, P Costa, V Oliveira, NCM Gomes… - Antibiotics, 2024 - mdpi.com
Urinary tract infections (UTIs) caused by resistant Klebsiella pneumoniae can lead to severe
clinical complications and even death. An alternative treatment option for infected patients is …

Phages for treatment of Klebsiella pneumoniae infections

BM Zaki, AH Hussein, TA Hakim, MS Fayez… - Progress in Molecular …, 2023 - Elsevier
Klebsiella pneumoniae is an opportunistic pathogen involved in both hospital-and
community-acquired infections. K. pneumoniae is associated with various infections …

Genome sequences of five Klebsiella bacteriophages that belong to the genus Jiaodavirus

TL Peters, CD Urick, M Georges, KA Burke… - Microbiology …, 2024 - journals.asm.org
We describe the genomes of five lytic Klebsiella pneumoniae myophages, therapeutic
candidates, that belong to the family Straboviridae and genus Jiaodavirus. The genomes …