The general transcription factors of RNA polymerase II. Publisher Logo Genes &
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Ternary complexes of DNA-dependent RNA polymerase with its DNA template and nascent
transcript are central intermediates in transcription. In recent years, several unusual …

P-TEFb is a key regulator of the process controlling the processivity of RNA polymerase II
and possesses a kinase activity that can phosphorylate the carboxy-terminal domain of the …

Higher‐order multi‐protein complexes such as RNA polymerase II (Pol II) complexes with
transcription initiation factors are often not amenable to X‐ray structure determination. Here …

In all domains of life, elongating RNA polymerases require the assistance of accessory
factors to maintain their processivity and regulate their rate. Among these elongation factors …

TFIIF (RAP30/74) is a general initiation factor that also increases the rate of elongation by
RNA polymerase II. A two-hybrid screen for RAP74-interacting proteins produced cDNAs …

Synthesis of eukaryotic messenger RNA by RNA polymerase II is governed by the concerted
action of a set of general transcription factors that control the activity of polymerase during …

Mammalian transcription factor IIF (TFIIF) is a heterodimer composed of approximately 30-
kDa (RAP30) and approximately 70-kDa (RAP74) subunits. TFIIF has been shown to bind …

Transcription factor (TF) IIF is a multifunctional RNA polymerase II transcription factor that
has well established roles in both transcription initiation, where it functions as a component …

Many changes must occur to the RNA polymerase II (pol II) transcription complex as it makes
the transition from initiation into transcript elongation. During this intermediate phase of …