▪ Abstract The cellular stress response is a universal mechanism of extraordinary
physiological/pathophysiological significance. It represents a defense reaction of cells to …

The importance of safer approaches for gene therapy has been underscored by a series of
severe adverse events (SAEs) observed in patients involved in clinical trials for Severe …

The process of homologous recombination is a major DNA repair pathway that operates on
DNA double-strand breaks, and possibly other kinds of DNA lesions, to promote error-free …

Plant mitochondria have a complex and peculiar genetic system. They have the largest
genomes, as compared to organelles from other eukaryotic organisms. These can expand …

DNA repair is an essential process for preserving genome integrity in all organisms. In
eukaryotes, recombinational repair is choreographed by multiprotein complexes that are …

Mutations in the BRCA2 (breast cancer susceptibility gene 2) tumor suppressor lead to
chromosomal instability due to defects in the repair of double-strand DNA breaks (DSBs) by …

▪ Abstract The process of homologous recombination promotes error-free repair of double-
strand breaks and is essential for meiosis. Central to the process of homologous …

Homology search and DNA strand–exchange reactions are central to homologous
recombination in meiosis. During meiosis, these processes are regulated such that the …

Processing of DNA in replication, repair and recombination pathways in cells of all
organisms requires the participation of at least one major single-stranded DNA (ssDNA) …

When duplex DNA is altered in almost any way (replicated, recombined, or repaired), single
strands of DNA are usually intermediates, and single-stranded DNA binding (SSB) proteins …