Nanoparticle-mediated drug delivery for the treatment of cardiovascular diseases

R Pala, VT Anju, M Dyavaiah, S Busi… - International journal of …, 2020 - Taylor & Francis
Cardiovascular diseases (CVDs) are one of the foremost causes of high morbidity and
mortality globally. Preventive, diagnostic, and treatment measures available for CVDs are …

Pharmacological activities and mechanisms of hirudin and its derivatives-a review

C Junren, X Xiaofang, Z Huiqiong, L Gangmin… - Frontiers in …, 2021 - frontiersin.org
Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also
known as “Shuizhi” in traditional Chinese medicine), is the strongest natural specific inhibitor …

Biomimetic Nanoplatelets to Target Delivery Hirudin for Site‐Specific Photothermal/Photodynamic Thrombolysis and Preventing Venous Thrombus Formation

S Li, K Zhang, Z Ma, W Zhang, Z Song, W Wang, H Han - Small, 2022 - Wiley Online Library
Due to the high recurrence rate and mortality of venous thrombosis, there is an urgent need
for research on antithrombotic strategies. Because of the short half‐life, poor targeting …

[HTML][HTML] Recent advances on nanoparticle-based therapies for cardiovascular diseases

RS Soumya, KG Raghu - Journal of Cardiology, 2023 - Elsevier
Nanoparticles are exclusively suitable for studying and developing potential therapies
against cardiovascular diseases (CVD) because of their size, fine-tunable properties, and …

Nano-medicine for thrombosis: a precise diagnosis and treatment strategy

M Su, Q Dai, C Chen, Y Zeng, C Chu, G Liu - Nano-Micro Letters, 2020 - Springer
Thrombosis is a global health issue and one of the leading factors of death. However, its
diagnosis has been limited to the late stages, and its therapeutic window is too narrow to …

Mechanisms of thrombosis and research progress on targeted antithrombotic drugs

L Zhang, Z Li, X Ye, Z Chen, ZS Chen - Drug Discovery Today, 2021 - Elsevier
Globally, the incidence of thromboembolic diseases has increased in recent years,
accompanied by an increase in patient mortality. Currently, several targeting delivery …

Prevention and treatment of atherothrombosis: Potential impact of nanotechnology

AB Nguyen, O Iqbal, RC Block, SA Mousa - Vascular Pharmacology, 2023 - Elsevier
Complications with atherosclerosis can often lead to fatal clot formation and blood vessel
occlusion–also known as atherothrombosis. A key component to the development of …

Recent advances in nanomaterials for diagnosis, treatments, and neurorestoration in ischemic stroke

X Lin, N Li, H Tang - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Stroke is a major public health issue, corresponding to the second cause of mortality and the
first cause of severe disability. Ischemic stroke is the most common type of stroke …

Thrombin-responsive engineered nanoexcavator with full-thickness infiltration capability for pharmaceutical-free deep venous thrombosis theranostics

A Yang, B Qiao, EM Strohm, J Cao, Z Wang… - Biomaterials …, 2020 - pubs.rsc.org
Although nanotechnology has shown great promise for treating multiple vascular diseases
in recent years, simultaneous noninvasive detection and efficient dissolution of deep venous …

Synthesis and characterization of a PAMAM dendrimer nanocarrier functionalized by HA for targeted gene delivery systems and evaluation in vitro

H Hu, H Wang, S Liang, X Li… - Journal of Biomaterials …, 2021 - Taylor & Francis
Abstract Poly (amido-amine)(PAMAM), one of the most widely studied dendrimers in the field
of drug and gene delivery, can enhance the stability of DNA and deliver it to cell cytosol; …