Hypoxia-inducible factor (HIF)-1α directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)

ZB Han, H Ren, H Zhao, Y Chi, K Chen, B Zhou… - …, 2008 - academic.oup.com
Stem cell factor (SCF) plays important roles in tumor growth and angiogenesis. However, its
regulatory mechanism remains largely undefined. Here, we report that hypoxia upregulated …

Restricted leptin antagonism as a therapeutic approach to treatment of autoimmune diseases

A Babaei, SH Zarkesh-Esfahani, E Bahrami, RJ Ross - Hormones, 2011 - Springer
Leptin, the adipocyte derived hormone, has a pivotal role in regulating energy homeostasis
and appetite. Beyond this essential role in bodyweight control, leptin also regulates the …

Prostate-specific membrane antigen as a marker of pancreatic cancer cells

H Ren, H Zhang, X Wang, J Liu, Z Yuan, J Hao - Medical Oncology, 2014 - Springer
The aim of this study was to identify the expression of prostate-specific membrane antigen
(PSMA) and analyze the correlation between PSMA with clinical characteristics in patients …

Leptin increases in Vogt–Koyanagi–Harada (VKH) disease and promotes cell proliferation and inflammatory cytokine secretion

L Liu, P Yang, H He, X Lin, L Jiang, W Chi… - British journal of …, 2008 - bjo.bmj.com
Backgroud/aims: Leptin has recently been found to play an important role in the
development of autoimmune diseases. Our study is designed to investigate the expression …

Obesity is associated with adverse outcomes in primary immune thrombocytopenia-a retrospective single-center study

Z Xiao, Z He, HLL Nguyen, RK Thakur… - Annals of …, 2024 - Springer
The pathophysiology of immune thrombocytopenia (ITP) involves immune-mediated platelet
destruction. The presence of adipose tissue in obese individuals creates an inflammatory …

The role of leptin in childhood immune thrombocytopenia (ITP): an anti-inflammatory agent?

I Thomas, I Panagoulias, I Aggeletopoulou… - International Journal of …, 2021 - mdpi.com
To investigate the effect of leptin in childhood ITP, we measured plasma leptin in 39 children
with acute ITP, after treatment and in remission, and in 33 healthy age/BMI-matched …

Platelet antibodies, activated platelets and serum leptin in childhood immune thrombocytopenic purpura

H Badrawy, KI Elsayh, AM Zahran… - Acta Haematologica, 2013 - karger.com
Background/Aim: The aim of this study was to evaluate the levels of platelet-associated
antibodies (PAIgG and PAIgM), activated platelets and serum leptin in children with acute …

Platelet and white blood cell counts correlate with leptin and body mass index in Japanese adolescents

J Takaya, Y Tanabe, N Nomura, M Minami… - Clinical Pediatric …, 2024 - jstage.jst.go.jp
Obesity is associated with mild chronic inflammation, frequently observed along with
increased platelet and white blood cell (WBC) levels in adults. We aimed to clarify the …

[HTML][HTML] An overview of leptin and the Th1/Th2 balance

BB Díaz, IM Rodríguez, DA González… - Open Journal of …, 2014 - scirp.org
Adipocytes produce hormones and adipokines, among others leptin, with metabolic and
inflammatory responses. The role of leptin involves different subsets of the immune system …

Elicitation of utility scores in Canada for immune thrombocytopenia treated with romiplostim or watch and rescue

M Iskedjian, AT Tinmouth, DM Arnold… - Journal of Medical …, 2012 - Taylor & Francis
Objectives: The objective of this study was to obtain utilities, or preference-based quality-of-
life values, from the Canadian general public, for potential health states experienced by …